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Propofol Versus Volatile Anesthesia in Post Operative Pain Management

This study has been terminated.
(Enrolling of participants has halted and the results are being gathered)
Information provided by (Responsible Party):
The Cleveland Clinic Identifier:
First received: July 7, 2008
Last updated: July 18, 2016
Last verified: July 2016
The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.

Condition Intervention
Varicose Vein Postoperative Pain Drug: propofol Drug: sevoflurane

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Do Patients Anesthetized With Propofol Have Less Pain Than Those Anesthetized With Volatile?

Resource links provided by NLM:

Further study details as provided by The Cleveland Clinic:

Primary Outcome Measures:
  • The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning. [ Time Frame: first post operative morning ]

Secondary Outcome Measures:
  • To determine the average pain score for each group during the first four hours of recovery after surgery. [ Time Frame: 30 minute intervals for first 4 hours post operatively ]

Enrollment: 90
Study Start Date: September 2010
Study Completion Date: May 2014
Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Patients will receive propofol anesthesia during varicose vein stripping surgery.
Drug: propofol
propofol anesthesia 3-5mg/kg
Other Name: Diprivan
Active Comparator: 2
Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.
Drug: sevoflurane
sevoflurane anesthesia

Detailed Description:
Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Participants will undergo a stripping operation for varicose veins
  • Surgery will be performed by one physician only
  • Written informed consent

Exclusion Criteria:

  • Any contraindications to the proposed interventions
  • Procedures done under regional anesthesia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00712517

Olga Plattner , MD
Vienna, Austria
Sponsors and Collaborators
The Cleveland Clinic
Principal Investigator: Olga Plattner, MD Medical University of Vienna
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: The Cleveland Clinic Identifier: NCT00712517     History of Changes
Other Study ID Numbers: 42908
Study First Received: July 7, 2008
Last Updated: July 18, 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by The Cleveland Clinic:
postoperative pain
varicose vein

Additional relevant MeSH terms:
Pain, Postoperative
Varicose Veins
Neurologic Manifestations
Nervous System Diseases
Postoperative Complications
Pathologic Processes
Signs and Symptoms
Vascular Diseases
Cardiovascular Diseases
Central Nervous System Depressants
Physiological Effects of Drugs
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Platelet Aggregation Inhibitors
Anesthetics, Inhalation processed this record on September 21, 2017