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Trial record 56 of 228 for:    EDN1

Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00712192
Recruitment Status : Completed
First Posted : July 9, 2008
Last Update Posted : July 9, 2008
Information provided by:
Far Eastern Memorial Hospital

Brief Summary:
Although the long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest may lead to significantly impaired wound healing and post-operative pain. To this end, endoscopic saphenous vein harvesting techniques have been shown to reduce post-operative morbidity. Studies have shown that endothelial integrity and luminal nitric oxide synthase (NOS) are better preserved with novel "no-touch" techniques; however, the effect and the associated mechanism of endoscopic vein harvest on endothelial integrity and function remain unknown. Therefore, in the present proposal, we will collect the saphenous vein segements immediately after harvesting, reperfusion, and grafting, and then use enzyme-linked immunosorbant assay (ELISA), immunohistochemical staining (IHC), and real-time polymerase chain reaction (RT-PCR) to detect the expression and distribution of endothelial NOS (eNOS), endothelin-1 (ET-1), vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1(PECAM-1) at protein and RNA levels in the endothelium of saphenous veins. The major aim of this study is to elucidate the effect and mechanism of endoscopic saphenous vein harvesting on endothelial properties as compare to conventional open vein harvest technique.

Condition or disease Intervention/treatment Phase
Coronary Artery Disease Procedure: coronary artery bypass grafting Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 34 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Impact on Endothelial Function and Integrity by Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
Study Start Date : January 2007
Actual Primary Completion Date : December 2007
Actual Study Completion Date : December 2007

Resource links provided by the National Library of Medicine

Intervention Details:
  • Procedure: coronary artery bypass grafting
    patient with coroary artery diseases underwent coronary artery bypass grafting surgery

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patient with coronary artery disease underwent coronary artery bypass grafting in our hospital

Exclusion Criteria:

  • no

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Responsible Party: Shih-Hong Huang, Far Eastern Memorial Hospital Identifier: NCT00712192     History of Changes
Other Study ID Numbers: 95016
FEMH - 95 - C -002
First Posted: July 9, 2008    Key Record Dates
Last Update Posted: July 9, 2008
Last Verified: July 2008
Keywords provided by Far Eastern Memorial Hospital:
coronary artery bypass grafting
endoscopic vein harvest
saphenous vein
endothelial cells
Additional relevant MeSH terms:
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Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases