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Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting

This study has been completed.
Information provided by:
Far Eastern Memorial Hospital Identifier:
First received: July 7, 2008
Last updated: July 8, 2008
Last verified: July 2008
Although the long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest may lead to significantly impaired wound healing and post-operative pain. To this end, endoscopic saphenous vein harvesting techniques have been shown to reduce post-operative morbidity. Studies have shown that endothelial integrity and luminal nitric oxide synthase (NOS) are better preserved with novel "no-touch" techniques; however, the effect and the associated mechanism of endoscopic vein harvest on endothelial integrity and function remain unknown. Therefore, in the present proposal, we will collect the saphenous vein segements immediately after harvesting, reperfusion, and grafting, and then use enzyme-linked immunosorbant assay (ELISA), immunohistochemical staining (IHC), and real-time polymerase chain reaction (RT-PCR) to detect the expression and distribution of endothelial NOS (eNOS), endothelin-1 (ET-1), vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1(PECAM-1) at protein and RNA levels in the endothelium of saphenous veins. The major aim of this study is to elucidate the effect and mechanism of endoscopic saphenous vein harvesting on endothelial properties as compare to conventional open vein harvest technique.

Condition Intervention
Coronary Artery Disease
Procedure: coronary artery bypass grafting

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: The Impact on Endothelial Function and Integrity by Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting

Resource links provided by NLM:

Further study details as provided by Far Eastern Memorial Hospital:

Enrollment: 34
Study Start Date: January 2007
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: coronary artery bypass grafting
    patient with coroary artery diseases underwent coronary artery bypass grafting surgery

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patient with coronary artery disease underwent coronary artery bypass grafting in our hospital

Exclusion Criteria:

  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Responsible Party: Shih-Hong Huang, Far Eastern Memorial Hospital Identifier: NCT00712192     History of Changes
Other Study ID Numbers: 95016
FEMH - 95 - C -002
Study First Received: July 7, 2008
Last Updated: July 8, 2008

Keywords provided by Far Eastern Memorial Hospital:
coronary artery bypass grafting
endoscopic vein harvest
saphenous vein
endothelial cells

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on May 25, 2017