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Sunscreen: Persistence of Sun Protection Factor and the Influence on Vitamin D (sunscreen)

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ClinicalTrials.gov Identifier: NCT00711256
Recruitment Status : Unknown
Verified April 2008 by Bispebjerg Hospital.
Recruitment status was:  Recruiting
First Posted : July 8, 2008
Last Update Posted : July 8, 2008
Sponsor:
Information provided by:
Bispebjerg Hospital

Brief Summary:
The investigators want to investigate whether sunscreen is removed by clothing and to what extend when the amount of sunscreen applied varies.Does clothing reduce the SPF when clothes are put on 20, 8, or 4 minutes after sunscreen application? The investigators also want to investigate the persistence of sunscreen during eight hours indoor. How much does the SPF reduces? Furthermore, we want to investigate whether sunscreen in the layers 2, 1, and 0.5 mg/cm2 reduce the vitamin D production in the skin.

Condition or disease Intervention/treatment Phase
Vitamin D Production in the Skin Sunscreen Persistence Other: sunscreen MATAS sunlotion SPF 8 Radiation: UVB light Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 80 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Sunscreen Removal by Clothing Meassured in Vivo. Sun Protection Factor Persistence During a Day Indoor Without Physical Activity. Does Sunscreen Reduce Vitamin D?
Study Start Date : July 2008
Estimated Primary Completion Date : August 2008
Estimated Study Completion Date : November 2008

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Arm Intervention/treatment
Active Comparator: 1
No sunscreen applied
Radiation: UVB light
duration 4 times 1 minute radiation on the trunk.

Active Comparator: 2
Sunscreen applied 0.5 mg/cm2
Radiation: UVB light
duration 4 times 1 minute radiation on the trunk.

Active Comparator: 3
Sunscreen applied 1mg/cm2
Radiation: UVB light
duration 4 times 1 minute radiation on the trunk.

Active Comparator: 4
Sunscreen applied 2mg/cm2
Other: sunscreen MATAS sunlotion SPF 8
Other Name: MATAS sollotion. Matas Denmark, 3400 Alleroed

Radiation: UVB light
duration 4 times 1 minute radiation on the trunk.




Primary Outcome Measures :
  1. vitamin D (nmol) meassured in a blood sample. [ Time Frame: 5 days after sunscreen use and UV light exposure ]


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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy participants.
  • > 18 years.
  • Skin type I, II, and III.

Exclusion Criteria:

  • Pregnancy.
  • Medicin use.
  • Skin or other diseases.
  • The participants must not have been in solarium or gotten sun on their trunks in the 3 months before the study start and during the study.
  • Skin types IV and above.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00711256


Contacts
Contact: Hans Christian Wulf, Dr.med +45 3135 3155
Contact: Ditte Beyer, stud.med +45 2014 1423 beyer10@tiscali.dk

Locations
Denmark
Bispebjerg Hospital Recruiting
Copenhagen, Kbh Nv, Denmark, 2400
Contact: HC Wulf, Dr.med    +45 3531 3155      
Contact: Ditte Beyer, stud.med    +45 2014 1423    beyer10@tiscali.dk   
Principal Investigator: Ditte Beyer, stud.med         
Sponsors and Collaborators
Bispebjerg Hospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Bispebjerg Hospital. Dr. Hans Christian Wulf, Bispebjerg Hospital
ClinicalTrials.gov Identifier: NCT00711256     History of Changes
Other Study ID Numbers: H-B-2007-120
First Posted: July 8, 2008    Key Record Dates
Last Update Posted: July 8, 2008
Last Verified: April 2008

Keywords provided by Bispebjerg Hospital:
Sunscreen
Application
Vitamin D
Sun protection factor
Clothing

Additional relevant MeSH terms:
Vitamins
Vitamin D
Ergocalciferols
Sunscreening Agents
Micronutrients
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents
Radiation-Protective Agents
Protective Agents
Dermatologic Agents