Vitrification Versus Slow Freezing of Human Day 3 Embryos

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00710723
Recruitment Status : Unknown
Verified January 2008 by University Hospital, Gasthuisberg.
Recruitment status was:  Active, not recruiting
First Posted : July 4, 2008
Last Update Posted : July 4, 2008
Information provided by:
University Hospital, Gasthuisberg

Brief Summary:
In assisted reproduction technology (ART), cryopreservation of embryos maximizes the potential of IVF cycles. Currently different cryopreservation methods are used, the conventional slow freezing method and vitrification. There is, therefore an immediate need to assess which cryopreservation technique is preferential in human IVF. In this prospective randomised study conventional slow freezing and vitrification, using the Hemi-straw carrier system, of human day 3 embryos were compared.

Condition or disease Intervention/treatment Phase
Cleavage Stage, Ovum Procedure: vitrification Not Applicable

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 901 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Vitrification Versus Slow Freezing of Human Day 3 Embryos
Study Start Date : October 2005
Estimated Study Completion Date : December 2008

Arm Intervention/treatment
Experimental: 1
Procedure: vitrification
Vitrification using Hemi-straw carrier system.
No Intervention: 2
Slow freezing

Primary Outcome Measures :
  1. Pregnancy rate [ Time Frame: 9 months ]

Secondary Outcome Measures :
  1. survival rate after thawing of embryos [ Time Frame: 24 hours ]

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Ages Eligible for Study:   18 Years to 43 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Embryos of sufficient embryo quality: at least 6 cells on day 3 and less than 20 % fragmentation.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00710723

UZ Leuven
Leuven, Belgium, 3000
Sponsors and Collaborators
University Hospital, Gasthuisberg
Principal Investigator: D'Hooghe Thomas, Prof. Dr. UZ Leuven

Responsible Party: Prof. Dr. Thomas D'Hooghe, University Hospital, Gasthuisberg. Identifier: NCT00710723     History of Changes
Other Study ID Numbers: dwille1
First Posted: July 4, 2008    Key Record Dates
Last Update Posted: July 4, 2008
Last Verified: January 2008