To Study the Effects of Host Genetic Factors on Liver Cirrhosis and Hepatocellular Carcinoma (HCC)
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|ClinicalTrials.gov Identifier: NCT00709085|
Recruitment Status : Unknown
Verified November 2009 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : July 3, 2008
Last Update Posted : November 25, 2009
|Condition or disease|
Hepatocellular carcinoma (HCC) usually occurs in cirrhotic liver. Only 10-30% of HCC occur in non-cirrhotic liver. It has been suggested that etiological factors may differ for HCC which develop in cirrhotic liver: HCC in non-cirrhotic liver might be less often associated with viral infection and chronic alcoholism than HCC in cirrhotic livers. However, in any individual, the factors that determine HCC with or without cirrhosis remain unknown.
Cirrhosis is the end of fibrosis progression. The progress of liver fibrosis is a complex progress involving many cytokines related to activation of the hepatic stellate cells and progressive accumulation of extracellular matrix. The key enzymes responsible for deposition and degradation of all the protein component of extracellular matrix and basement membrane are matrix metalloproteinases.
To assess whether genetic variations in cytokines and matrix metalloproteinases result in diversity of liver cirrhosis and HCC, we conduct a case-control study of single nucleotide polymorphism analysis.
|Study Type :||Observational|
|Estimated Enrollment :||320 participants|
|Observational Model:||Case Control|
|Official Title:||Functional Genomics and Proteomics Towards and Understanding of Cell Signaling and Diseases--- Genomic and Proteomic Analyses of Liver Cells During Hepatitis Virus Infections and Cell Therapy (4/4)|
|Study Start Date :||April 2008|
|Estimated Primary Completion Date :||December 2009|
|Estimated Study Completion Date :||December 2009|
HCC patients without liver cirrhosis
HCC patients with liver cirrhosis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00709085
|Contact: Tzu-Min Hung, M.S.||886-2-2312-3456 ext email@example.com|
|National Taiwan University Hospital||Recruiting|
|Contact: Ming-Fu Chang, Ph.D. 886-2-2312-3456 ext 88217 firstname.lastname@example.org|
|Principal Investigator: Ming-Fu Chang, Ph.D.|
|Study Chair:||Ming-Fu Chang, Ph.D.||National Taiwan University College of Medicine|