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Levels of Circulating T Cells Expressing VLA-1 Collagen Receptors

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00708838
First Posted: July 2, 2008
Last Update Posted: July 2, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Sheba Medical Center
  Purpose
The examination of the percentage of peripheral T cells carrying VLA-1 in ischemic heart disease patients. The hypothesis is that the percentage levels of cells carrying this integrin rise according to the severity of the ischemic heart disease.

Condition
Ischemic Heart Disease

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: VLA-1 Receptors on Peripheral T Cells in Ischemic Heart Disease Patients

Resource links provided by NLM:


Further study details as provided by Sheba Medical Center:

Primary Outcome Measures:
  • The differance in percentage of T cells in the 5 different groups involved. [ Time Frame: 2002-2006 ]

Biospecimen Retention:   None Retained
Blood samples isolated from patients included in the study and anallysed by FACS

Enrollment: 151
Study Start Date: January 2002
Study Completion Date: February 2007
Primary Completion Date: January 2006 (Final data collection date for primary outcome measure)

Detailed Description:
Atherosclerosis is considered an inflammatory disease in which lymphocytes have an important role. The study was disigned to find out the changes in T cell levels carrying VLA-1 involvement in this process.
  Eligibility

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Criteria

Inclusion Criteria:

  • clinical diagnosis of acute MI for group 1
  • clinical diagnosis of ACSl for group 2
  • clinical diagnosis of Chronic Heart Disease for groups 3 and 4
  • Chest pain but normal heart scan for group 5

Exclusion Criteria:

  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Arik Asman, Sheba Medical Center, Heart Institute
ClinicalTrials.gov Identifier: NCT00708838     History of Changes
Other Study ID Numbers: SHEBA-02-2707-AA-CTIL
First Submitted: July 1, 2008
First Posted: July 2, 2008
Last Update Posted: July 2, 2008
Last Verified: July 2008

Additional relevant MeSH terms:
Ischemia
Heart Diseases
Myocardial Ischemia
Coronary Artery Disease
Pathologic Processes
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arteriosclerosis
Arterial Occlusive Diseases