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Levels of Circulating T Cells Expressing VLA-1 Collagen Receptors

This study has been completed.
Information provided by:
Sheba Medical Center Identifier:
First received: July 1, 2008
Last updated: NA
Last verified: July 2008
History: No changes posted
The examination of the percentage of peripheral T cells carrying VLA-1 in ischemic heart disease patients. The hypothesis is that the percentage levels of cells carrying this integrin rise according to the severity of the ischemic heart disease.

Ischemic Heart Disease

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: VLA-1 Receptors on Peripheral T Cells in Ischemic Heart Disease Patients

Resource links provided by NLM:

Further study details as provided by Sheba Medical Center:

Primary Outcome Measures:
  • The differance in percentage of T cells in the 5 different groups involved. [ Time Frame: 2002-2006 ]

Biospecimen Retention:   None Retained
Blood samples isolated from patients included in the study and anallysed by FACS

Enrollment: 151
Study Start Date: January 2002
Study Completion Date: February 2007
Primary Completion Date: January 2006 (Final data collection date for primary outcome measure)

Detailed Description:
Atherosclerosis is considered an inflammatory disease in which lymphocytes have an important role. The study was disigned to find out the changes in T cell levels carrying VLA-1 involvement in this process.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample

Inclusion Criteria:

  • clinical diagnosis of acute MI for group 1
  • clinical diagnosis of ACSl for group 2
  • clinical diagnosis of Chronic Heart Disease for groups 3 and 4
  • Chest pain but normal heart scan for group 5

Exclusion Criteria:

  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Responsible Party: Arik Asman, Sheba Medical Center, Heart Institute Identifier: NCT00708838     History of Changes
Other Study ID Numbers: SHEBA-02-2707-AA-CTIL
Study First Received: July 1, 2008
Last Updated: July 1, 2008

Additional relevant MeSH terms:
Heart Diseases
Myocardial Ischemia
Coronary Artery Disease
Pathologic Processes
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arterial Occlusive Diseases processed this record on September 21, 2017