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Levels of Circulating T Cells Expressing VLA-1 Collagen Receptors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00708838
Recruitment Status : Completed
First Posted : July 2, 2008
Last Update Posted : July 2, 2008
Information provided by:
Sheba Medical Center

Brief Summary:
The examination of the percentage of peripheral T cells carrying VLA-1 in ischemic heart disease patients. The hypothesis is that the percentage levels of cells carrying this integrin rise according to the severity of the ischemic heart disease.

Condition or disease
Ischemic Heart Disease

Detailed Description:
Atherosclerosis is considered an inflammatory disease in which lymphocytes have an important role. The study was disigned to find out the changes in T cell levels carrying VLA-1 involvement in this process.

Study Type : Observational
Actual Enrollment : 151 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: VLA-1 Receptors on Peripheral T Cells in Ischemic Heart Disease Patients
Study Start Date : January 2002
Primary Completion Date : January 2006
Study Completion Date : February 2007

Resource links provided by the National Library of Medicine

U.S. FDA Resources


Primary Outcome Measures :
  1. The differance in percentage of T cells in the 5 different groups involved. [ Time Frame: 2002-2006 ]

Biospecimen Retention:   None Retained
Blood samples isolated from patients included in the study and anallysed by FACS

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample

Inclusion Criteria:

  • clinical diagnosis of acute MI for group 1
  • clinical diagnosis of ACSl for group 2
  • clinical diagnosis of Chronic Heart Disease for groups 3 and 4
  • Chest pain but normal heart scan for group 5

Exclusion Criteria:

Responsible Party: Arik Asman, Sheba Medical Center, Heart Institute Identifier: NCT00708838     History of Changes
Other Study ID Numbers: SHEBA-02-2707-AA-CTIL
First Posted: July 2, 2008    Key Record Dates
Last Update Posted: July 2, 2008
Last Verified: July 2008

Additional relevant MeSH terms:
Heart Diseases
Myocardial Ischemia
Coronary Artery Disease
Pathologic Processes
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arterial Occlusive Diseases