Embryo Aneuploidies and Ovarian Stimulation
There is a considerable concern about the effects of controlled ovarian hyperstimulation (COH) for In Vitro Fertilization- Embryo Transfer (IVF-ET) on embryo quality and on the incidence of chromosomal abnormalities in oocytes and embryos.
The main question remaining is if COH may increase the aneuploidies rate in young and healthy women. Therefore, the primary endpoint of the present study is to analyse the incidence of chromosomal abnormalities in this group of patients (oocyte donors), either in oocytes obtained after a natural cycle or in those retrieved after a COH cycle. To get rid of the male factor influence, donated sperm will be used.
|Embryo Aneuploidies||Procedure: Preimplantation Genetic Diagnosis||Phase 4|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Incidence of EmbyoO Aneuploidies in Natural Versus Stimulated Cycles in the Same Women.|
- Embryo aneuploidies [ Time Frame: 2 cycles ]
|Study Start Date:||February 2008|
|Study Completion Date:||February 2010|
|Primary Completion Date:||February 2010 (Final data collection date for primary outcome measure)|
No Intervention: 1
Natural cycle oocyte donation
Active Comparator: 2
Stimulated cycle oocyte donation.
Procedure: Preimplantation Genetic Diagnosis
Preimplantation Genetic Diagnosis (PGD) is performed on the embryos resulting from these natural and stimulated cycles.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00707525
|Instituto Valenciano de Infertilidad|
|Valencia, Spain, 46015|