The Cytoadherence in Pediatric Malaria (CPM) Study (CPM)
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|ClinicalTrials.gov Identifier: NCT00707200|
Recruitment Status : Completed
First Posted : June 30, 2008
Last Update Posted : January 26, 2010
|Condition or disease|
|Plasmodium Falciparum Malaria|
|Study Type :||Observational|
|Estimated Enrollment :||2000 participants|
|Observational Model:||Case Control|
|Official Title:||Clinical Outcomes in Pediatric Plasmodium Falciparum Malaria According to Host Cytoadherence Factors|
|Study Start Date :||October 2007|
|Actual Primary Completion Date :||November 2009|
|Actual Study Completion Date :||November 2009|
Cases: Severe inpatient malaria, survivors or decedents. Severe malaria consists of any one or combination of severe malarial anemia (SMA), cerebral malaria (CM), lactic acidosis (LA), or a respiratory distress syndrome with hypoxia.
Controls: Controls consist of mildly-affected children with P falciparum malaria who are either managed as inpatients or outpatients.
- Combined severe morbidity & mortality [ Time Frame: Discharge ]
- Laboratory indices of potential cytoadhesion (lactate, cell counts) [ Time Frame: Presentation ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00707200
|Mulago Hospital Acute Care Unit & Makerere University Department of Paediatrics & Child Health|
|Study Director:||Nicolette Nabukeera-Barungi, MBChB, MMEd||Mulago Hospital/Makerere University (lead local investigator)|