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The Genetics of Cardiomyopathy and Heart Failure

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ClinicalTrials.gov Identifier: NCT00703443
Recruitment Status : Withdrawn (Non applicable clinical trial)
First Posted : June 23, 2008
Last Update Posted : January 25, 2021
Information provided by (Responsible Party):
University of California, Irvine

Brief Summary:
The purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.

Condition or disease
Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Mitochondrial Cardiomyopathy Noncompaction Cardiomyopathy Restrictive Cardiomyopathy

Detailed Description:
The purpose of this research study is to explore the causes and inheritances of cardiomyopathies. Cardiomyopathies are serious medical conditions that result in a wide range of cardiac problems, from no symptoms at all to heart failure. The underlying genetics of cardiomyopathies are poorly understood. This study will collect personal, family, and medical history information to create a database of participants with cardiomyopathies. This information will be used to identify inheritance patterns within families with cardiomyopathies. In addition, samples from participants will be studied in the lab to see if any changes in their genetic information can be identified that would cause a cardiomyopathy. Overall, the research study is aimed at determining the cause of these cardiac conditions so that tests and treatments might be developed in the future.

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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Family-Based
Time Perspective: Retrospective
Official Title: The Genetics of Cardiomyopathy and Heart Failure
Study Start Date : April 2007
Actual Primary Completion Date : April 2007
Actual Study Completion Date : April 2007

Biospecimen Retention:   Samples With DNA
Whole blood, Saliva, Buccal cells

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
We are recruiting both local participants (who have been evaluated at UCI) and remote participants (who have been referred from outside UCI) with familial and simplex cases of hypertrophic, dilated, noncompaction, restrictive, and mitochondrial cardiomyopathies. As a control group, we are also recruiting patients with nuclear mutations known to increase the risk of cardiomyopathy, but who have not themselves developed cardiomyopathy.

Inclusion Criteria:

  • Individuals with a diagnosis of cardiomyopathy
  • Family members of individuals with a diagnosis of cardiomyopathy
  • Individuals with a nuclear mutation shown to confer risk of cardiomyopathy but who do not themselves have cardiomyopathy

Exclusion Criteria:

  • Individuals who do not have cardiomyopathy, a relative with cardiomyopathy, or a nuclear mutation predisposing to cardiomyopathy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00703443

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United States, California
University of California, Irvine
Irvine, California, United States, 92697
Sponsors and Collaborators
University of California, Irvine
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Principal Investigator: Michael V Zaragoza, M.D., Ph.D. University of California, Irvine
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Responsible Party: University of California, Irvine
ClinicalTrials.gov Identifier: NCT00703443    
Other Study ID Numbers: HS# 2007-5577
NIH/NHLBI 5K08HL081222-02
First Posted: June 23, 2008    Key Record Dates
Last Update Posted: January 25, 2021
Last Verified: January 2021
Keywords provided by University of California, Irvine:
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Mitochondrial Cardiomyopathy
Noncompaction Cardiomyopathy
Restrictive Cardiomyopathy
Heart Failure
Additional relevant MeSH terms:
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Heart Failure
Cardiomyopathy, Hypertrophic
Cardiomyopathy, Dilated
Cardiomyopathy, Restrictive
Heart Diseases
Cardiovascular Diseases
Pathological Conditions, Anatomical
Aortic Stenosis, Subvalvular
Aortic Valve Stenosis
Aortic Valve Disease
Heart Valve Diseases
Genetic Diseases, Inborn