The Genetics of Cardiomyopathy and Heart Failure

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ClinicalTrials.gov Identifier: NCT00703443

Recruitment Status : Withdrawn (Non applicable clinical trial)

First Posted : June 23, 2008

Last Update Posted : January 25, 2021

Sponsor:

Information provided by (Responsible Party):

University of California, Irvine

Study Description

Brief Summary:

The purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.

Condition or disease
Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Mitochondrial Cardiomyopathy Noncompaction Cardiomyopathy Restrictive Cardiomyopathy

Detailed Description:

The purpose of this research study is to explore the causes and inheritances of cardiomyopathies. Cardiomyopathies are serious medical conditions that result in a wide range of cardiac problems, from no symptoms at all to heart failure. The underlying genetics of cardiomyopathies are poorly understood. This study will collect personal, family, and medical history information to create a database of participants with cardiomyopathies. This information will be used to identify inheritance patterns within families with cardiomyopathies. In addition, samples from participants will be studied in the lab to see if any changes in their genetic information can be identified that would cause a cardiomyopathy. Overall, the research study is aimed at determining the cause of these cardiac conditions so that tests and treatments might be developed in the future.

Study Design

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Study Type :	Observational
Actual Enrollment :	0 participants
Observational Model:	Family-Based
Time Perspective:	Retrospective
Official Title:	The Genetics of Cardiomyopathy and Heart Failure
Study Start Date :	April 2007
Actual Primary Completion Date :	April 2007
Actual Study Completion Date :	April 2007

Resource links provided by the National Library of Medicine

MedlinePlus Genetics related topics: Familial hypertrophic cardiomyopathy Familial restrictive cardiomyopathy Familial dilated cardiomyopathy Left ventricular noncompaction X-linked dilated cardiomyopathy

MedlinePlus related topics: Cardiomyopathy Heart Failure

Genetic and Rare Diseases Information Center resources: Dilated Cardiomyopathy Aortic Valve Stenosis

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Biospecimen Retention: Samples With DNA

Whole blood, Saliva, Buccal cells

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:	Child, Adult, Older Adult
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

We are recruiting both local participants (who have been evaluated at UCI) and remote participants (who have been referred from outside UCI) with familial and simplex cases of hypertrophic, dilated, noncompaction, restrictive, and mitochondrial cardiomyopathies. As a control group, we are also recruiting patients with nuclear mutations known to increase the risk of cardiomyopathy, but who have not themselves developed cardiomyopathy.

Criteria

Inclusion Criteria:

Individuals with a diagnosis of cardiomyopathy
Family members of individuals with a diagnosis of cardiomyopathy
Individuals with a nuclear mutation shown to confer risk of cardiomyopathy but who do not themselves have cardiomyopathy

Exclusion Criteria:

Individuals who do not have cardiomyopathy, a relative with cardiomyopathy, or a nuclear mutation predisposing to cardiomyopathy

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00703443

Locations

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United States, California
University of California, Irvine
Irvine, California, United States, 92697

Sponsors and Collaborators

University of California, Irvine

Investigators

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Principal Investigator:	Michael V Zaragoza, M.D., Ph.D.	University of California, Irvine

More Information

Publications:

Zaragoza MV, Arbustini E, Narula J. Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology. Curr Opin Pediatr. 2007 Dec;19(6):619-27. Review.

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Responsible Party:	University of California, Irvine
ClinicalTrials.gov Identifier:	NCT00703443
Other Study ID Numbers:	HS# 2007-5577 NIH/NHLBI 5K08HL081222-02
First Posted:	June 23, 2008 Key Record Dates
Last Update Posted:	January 25, 2021
Last Verified:	January 2021

Keywords provided by University of California, Irvine:


Genetics Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Mitochondrial Cardiomyopathy	Noncompaction Cardiomyopathy Restrictive Cardiomyopathy Heart Failure

Additional relevant MeSH terms:

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Heart Failure Cardiomyopathies Cardiomyopathy, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy, Restrictive Hypertrophy Heart Diseases Cardiovascular Diseases	Pathological Conditions, Anatomical Aortic Stenosis, Subvalvular Aortic Valve Stenosis Aortic Valve Disease Heart Valve Diseases Cardiomegaly Laminopathies Genetic Diseases, Inborn

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