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Immunoregulation of Periodontal Disease

This study has been completed.
Information provided by (Responsible Party):
Assistance Publique Hopitaux De Marseille Identifier:
First received: June 18, 2008
Last updated: August 27, 2014
Last verified: August 2014
Our design is to test in hospital practice a selection of immune parameters that could assess the pathophysiology and progression of periodontal lesions.

Condition Intervention
Periodontal Disease Other: Blood sampling

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Immunoregulation of Periodontal Disease

Resource links provided by NLM:

Further study details as provided by Assistance Publique Hopitaux De Marseille:

Primary Outcome Measures:
  • Percentage of positive cells and intensity of expression for the molecules of surface studied there cytometric in stream [ Time Frame: 24 months ]

Secondary Outcome Measures:
  • Rate of secretion of cytokines and the other substances [ Time Frame: 24 months ]
  • Detection and quantification of ARN messengers [ Time Frame: 24 months ]

Enrollment: 23
Study Start Date: August 2008
Study Completion Date: July 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Patients achieve of parodontopathies
Other: Blood sampling
Analysis of the PNN, analysis of the monocytes
Placebo Comparator: 2
Patients without parodontales diseases
Other: Blood sampling
Analysis of the PNN, analysis of the monocytes

Detailed Description:
These parameters will be measured in 25 healthy volunteers and 25 moderate-to severe periodontal disese patients. Phagocytes will be tested phenotypically and functionally, both ex vivo and in vitro.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Persons appearing spontaneously at the consultation of parodontologie for parodontale disease,
  • persons agreeing to undergo a sampling of blood intended for the search

Exclusion Criteria:

  • Presence of a chronic or pointed pathology,
  • an age 18-year-old subordinate or 65-year-old superior,
  • pregnant women,
  Contacts and Locations
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Please refer to this study by its identifier: NCT00702429

Hopital de la Conception- Laboratoire d'Immunologie
Marseille, France, 13274
Sponsors and Collaborators
Assistance Publique Hopitaux De Marseille
Principal Investigator: Joana VITTE, MD Assistance Publique des Hôpitaux de Marseille
  More Information

Responsible Party: Assistance Publique Hopitaux De Marseille Identifier: NCT00702429     History of Changes
Other Study ID Numbers: 2007-A00632-51
Study First Received: June 18, 2008
Last Updated: August 27, 2014

Additional relevant MeSH terms:
Periodontal Diseases
Gingival Diseases
Mouth Diseases
Stomatognathic Diseases processed this record on September 21, 2017