We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Immunoregulation of Periodontal Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00702429
Recruitment Status : Completed
First Posted : June 20, 2008
Last Update Posted : August 28, 2014
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Our design is to test in hospital practice a selection of immune parameters that could assess the pathophysiology and progression of periodontal lesions.

Condition or disease Intervention/treatment
Periodontal Disease Other: Blood sampling

Detailed Description:
These parameters will be measured in 25 healthy volunteers and 25 moderate-to severe periodontal disese patients. Phagocytes will be tested phenotypically and functionally, both ex vivo and in vitro.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 23 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Immunoregulation of Periodontal Disease
Study Start Date : August 2008
Primary Completion Date : July 2010
Study Completion Date : July 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Gum Disease
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: 1
Patients achieve of parodontopathies
Other: Blood sampling
Analysis of the PNN, analysis of the monocytes
Placebo Comparator: 2
Patients without parodontales diseases
Other: Blood sampling
Analysis of the PNN, analysis of the monocytes


Outcome Measures

Primary Outcome Measures :
  1. Percentage of positive cells and intensity of expression for the molecules of surface studied there cytometric in stream [ Time Frame: 24 months ]

Secondary Outcome Measures :
  1. Rate of secretion of cytokines and the other substances [ Time Frame: 24 months ]
  2. Detection and quantification of ARN messengers [ Time Frame: 24 months ]

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Persons appearing spontaneously at the consultation of parodontologie for parodontale disease,
  • persons agreeing to undergo a sampling of blood intended for the search

Exclusion Criteria:

  • Presence of a chronic or pointed pathology,
  • an age 18-year-old subordinate or 65-year-old superior,
  • pregnant women,
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00702429


Locations
France
Hopital de la Conception- Laboratoire d'Immunologie
Marseille, France, 13274
Sponsors and Collaborators
Assistance Publique Hopitaux De Marseille
Investigators
Principal Investigator: Joana VITTE, MD Assistance Publique des Hôpitaux de Marseille
More Information

Responsible Party: Assistance Publique Hopitaux De Marseille
ClinicalTrials.gov Identifier: NCT00702429     History of Changes
Other Study ID Numbers: 2007-A00632-51
First Posted: June 20, 2008    Key Record Dates
Last Update Posted: August 28, 2014
Last Verified: August 2014

Additional relevant MeSH terms:
Periodontal Diseases
Gingival Diseases
Mouth Diseases
Stomatognathic Diseases