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The Role of Diet and Lifestyle in Breast Cancer Survival (DietCompLyf)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2014 by University College London Hospitals.
Recruitment status was:  Active, not recruiting
United Kingdom Clinical Research Collaboration
Information provided by:
University College London Hospitals Identifier:
First received: June 13, 2008
Last updated: May 19, 2014
Last verified: May 2014
Diet has been found to influence hormone production and metabolism which in turn could affect the incidence of hormone related cancers. Consumption of soy-containing foods, known to be rich in phytoestrogens, is thought to be one of the chemoprotective factors against breast cancer in Asian populations. Phytoestrogens have a wide range of metabolic effects and may have a role in effecting breast cancer risk. Although there is mounting evidence of the positive influence of phytoestrogens on breast cancer risk, very little research has been carried out in humans as to the effects of phytoestrogens on breast cancer recurrence and survival. The DietCompLyf study aims to explore this effect by carrying out an observational study in 3,000 breast cancer women in the UK. The effects of diet, lifestyle practices and use of complementary treatments will also be investigated. Participants are recruited 9-15 months post-diagnosis and followed up for 5 years. Questionnaires as well as blood and urine samples are collected annually.

Breast Cancer

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Role of Diet, Complementary Treatment and Lifestyle in Breast Cancer Progression and Survival

Resource links provided by NLM:

Further study details as provided by University College London Hospitals:

Primary Outcome Measures:
  • To assess the association between phytoestrogens and relapse free survival [ Time Frame: Up to 5 years post-diagnosis ]

Secondary Outcome Measures:
  • To assess the association between phytoestrogens and event free survival [ Time Frame: Up to 5 years post-diagnosis ]
  • To assess the association between phytoestrogens and recurrence free survival [ Time Frame: Up to 5 years post-diagnosis ]

Biospecimen Retention:   Samples With DNA
Serum, plasma, buffy coat, urine

Enrollment: 3390
Study Start Date: January 2005
Estimated Study Completion Date: December 2014
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Detailed Description:

Women matching the eligibility criteria are consented at breast cancer follow-up hospital visits. Blood and urine samples are then collected and questionnaires are provided for the participants to take away and return within 4 weeks. The process of sample collection and questionnaire provision is repeated for visit at years 3 and 5.

Year 2 and 4 study visit vary in that questionnaires including a 7 day food diary are sent to participants at home to be filled in 7 days before their scheduled follow-up appointment. At hospital, blood and urine samples are collected as usual.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Breast cancer clinics in UK

Inclusion Criteria:

  • Women with histologically confirmed invasive primary breast cancer grades I to III.
  • age up to and including 75 years old

Exclusion Criteria:

  • Previous cancer with the exception of basal cell carcinoma
  • Concomitant primary cancer
  • Bilateral cancer of the breast
  • Psychological problems
  • Cognitive impairment
  • Poor understanding of English
  Contacts and Locations
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Please refer to this study by its identifier: NCT00701584

United Kingdom
University of Westminster
London, United Kingdom, W1W 6UW
Sponsors and Collaborators
University College London Hospitals
United Kingdom Clinical Research Collaboration
Principal Investigator: Miriam V Dwek, PhD University of Westminster
  More Information

Responsible Party: Director of Research and Developement, UCL Hospitals NHS Foundation Trust Identifier: NCT00701584     History of Changes
Other Study ID Numbers: 1456
Study First Received: June 13, 2008
Last Updated: May 19, 2014

Keywords provided by University College London Hospitals:
Breast cancer survival
breast cancer recurrence

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases processed this record on May 25, 2017