Hormonal Effects on Pain Perception (HEPP)
To investigate if labor pain is affected by mother's hormone levels.
The hormonal effects of pregnancy are well documented. Although differences in pain sensitivity between women and men are partly attributable to social conditioning and to psychosocial factors, many laboratory studies of humans have described sex differences in sensitivity to noxious stimuli, suggesting that biological mechanisms underlie such differences. Some animal studies have suggested that sensitivity to pain decreases during pregnancy because of the progressive activation of endogenous pain inhibitory systems. This effect may be mediated by pregnancy-associated hormones, in particular progesterone.
Pregnancy Associated Analgesia
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Hormonal Effects on Pain Perception|
- Change in heat pain threshold and tolerance [ Time Frame: 1 month ] [ Designated as safety issue: No ]
Biospecimen Retention: None Retained
|Study Start Date:||September 2008|
|Study Completion Date:||November 2014|
|Primary Completion Date:||November 2014 (Final data collection date for primary outcome measure)|
Term pregnant women
Healthy women scheduled for elective Cesarean section.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00699595
|United States, Alabama|
|University of Alabama at Birmingham|
|Birmingham, Alabama, United States, 35294|
|Principal Investigator:||Michael Froelich, MD, MS||University of Alabama at Birmingham|