Hormonal Effects on Pain Perception (HEPP)
|ClinicalTrials.gov Identifier: NCT00699595|
Recruitment Status : Completed
First Posted : June 18, 2008
Last Update Posted : November 11, 2014
To investigate if labor pain is affected by mother's hormone levels.
The hormonal effects of pregnancy are well documented. Although differences in pain sensitivity between women and men are partly attributable to social conditioning and to psychosocial factors, many laboratory studies of humans have described sex differences in sensitivity to noxious stimuli, suggesting that biological mechanisms underlie such differences. Some animal studies have suggested that sensitivity to pain decreases during pregnancy because of the progressive activation of endogenous pain inhibitory systems. This effect may be mediated by pregnancy-associated hormones, in particular progesterone.
|Condition or disease|
|Pregnancy Progesterone Levels Pregnancy Associated Analgesia|
|Study Type :||Observational|
|Actual Enrollment :||50 participants|
|Official Title:||Hormonal Effects on Pain Perception|
|Study Start Date :||September 2008|
|Actual Primary Completion Date :||November 2014|
|Actual Study Completion Date :||November 2014|
Term pregnant women
Healthy women scheduled for elective Cesarean section.
- Change in heat pain threshold and tolerance [ Time Frame: 1 month ]
Biospecimen Retention: None Retained
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00699595
|United States, Alabama|
|University of Alabama at Birmingham|
|Birmingham, Alabama, United States, 35294|
|Principal Investigator:||Michael Froelich, MD, MS||University of Alabama at Birmingham|