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Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2009 by Dow University of Health Sciences.
Recruitment status was:  Active, not recruiting
Information provided by:
Dow University of Health Sciences Identifier:
First received: June 13, 2008
Last updated: January 30, 2009
Last verified: January 2009
Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication. Tear proteins are easy to collect causing no harm to a patient and different studies indicate that tear proteins of diabetic patients are significantly different from non diabetic population. This difference in the composition of tear proteins become more pronounced with advancement of diabetic retinopathy.

Diabetes Mellitus

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Tear Proteins and Diabetic Retinopathy

Resource links provided by NLM:

Further study details as provided by Dow University of Health Sciences:

Estimated Enrollment: 350
Study Start Date: January 2009
Estimated Study Completion Date: June 2011
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Non diabetic
Normal age and sex matched population
Grade 1
Diabetic population with no retinopathy or Mild non proliferative diabetic retinopathy
Grade 2
Moderate non proliferative diabetic retinopathy
Grade 3
Severe non proliferative diabetic retinopathy
Grade 4
Proliferative diabetic retinopathy and advanced diabetic eye disease

Detailed Description:

Diabetes mellitus causes a significant alteration in tear proteins. If we analyze tear proteins by means of electrophoresis, HPLC, and mass spectroscopy.

We can find different type of tear proteins in different grades of diabetic retinopathy these biomarkers can help in mass screening , diagnosis and management of diabetic population.


Ages Eligible for Study:   30 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
diabetic population

Inclusion Criteria:

  • diabetic patients with type 2 diabetes
  • age above 30
  • willing to participate

Exclusion Criteria:

  • ocular surface disorders.
  • collagen vascular diseases
  • Limbal hyperemia
  • previous ocular surgery
  • creatinine level above 1.0
  • liver diseases
  Contacts and Locations
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Please refer to this study by its identifier: NCT00698698

Dow University of Health Sciences
Karachi, Sindh, Pakistan, 75500
Sponsors and Collaborators
Dow University of Health Sciences
Principal Investigator: Dr. Jamshed Ahmed, FCPS Dow University of Health Sciences Pakistan
  More Information

Responsible Party: Dr.Jamshed Ahmed Assistant Professor, Dow university of Health Sciences Karachi Pakistan Identifier: NCT00698698     History of Changes
Other Study ID Numbers: Tear proteins
Study First Received: June 13, 2008
Last Updated: January 30, 2009

Keywords provided by Dow University of Health Sciences:
tear proteins
diabetic retinopathy
Mass spectroscopy

Additional relevant MeSH terms:
Diabetes Mellitus
Retinal Diseases
Diabetic Retinopathy
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Eye Diseases
Diabetic Angiopathies
Vascular Diseases
Cardiovascular Diseases
Diabetes Complications processed this record on August 21, 2017