Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics
Recruitment status was Active, not recruiting
Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication. Tear proteins are easy to collect causing no harm to a patient and different studies indicate that tear proteins of diabetic patients are significantly different from non diabetic population. This difference in the composition of tear proteins become more pronounced with advancement of diabetic retinopathy.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Tear Proteins and Diabetic Retinopathy|
|Study Start Date:||January 2009|
|Estimated Study Completion Date:||June 2011|
|Estimated Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
Normal age and sex matched population
Diabetic population with no retinopathy or Mild non proliferative diabetic retinopathy
Moderate non proliferative diabetic retinopathy
Severe non proliferative diabetic retinopathy
Proliferative diabetic retinopathy and advanced diabetic eye disease
Diabetes mellitus causes a significant alteration in tear proteins. If we analyze tear proteins by means of electrophoresis, HPLC, and mass spectroscopy.
We can find different type of tear proteins in different grades of diabetic retinopathy these biomarkers can help in mass screening , diagnosis and management of diabetic population.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00698698
|Dow University of Health Sciences|
|Karachi, Sindh, Pakistan, 75500|
|Principal Investigator:||Dr. Jamshed Ahmed, FCPS||Dow University of Health Sciences Pakistan|