Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock (VaCoSS)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00698048|
Recruitment Status : Completed
First Posted : June 16, 2008
Last Update Posted : September 9, 2015
Patients with severe infection can develop very low blood pressure. There are many mechanisms leading to this, and one of them appears to involve a hormone called vasopressin. In children as compared to adults, the mechanism and response to low blood pressure are different for reasons that are not clear. One possibility is the difference in the production and/or response to vasopressin. Vasopressin has become part of the treatment of children with low blood pressure in the setting of severe infection, when other treatment has failed, but its use is on the basis of animal and adult studies. The exact timing and dose is uncertain.
In this research study, the patients will receive standard treatment for sepsis and septic shock, and the investigators will measure the blood levels of vasopressin and a related compound called copeptin (both are required to understand the mechanism of control involved). Blood will need to be taken from patients without any sepsis so as to be able to compare the values in health and in sickness. The patient groups the investigators have chosen for this are those children who will have blood taken anyway as part of their routine care. The aim of this study is to develop an understanding of the body's hormonal response (with respect to vasopressin) to severe infection in children. The long-term aim is to improve the care of critically ill children with severe infection by using the most appropriate dose of vasopressin at the most appropriate time.
|Condition or disease|
|Sepsis Septic Shock|
|Study Type :||Observational|
|Actual Enrollment :||136 participants|
|Official Title:||Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock|
|Study Start Date :||August 2008|
|Primary Completion Date :||December 2011|
|Study Completion Date :||December 2011|
- Vasopressin and copeptin levels [ Time Frame: First 5 days of admission ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00698048
|KK Women's and Children's Hospital|
|Singapore, Singapore, 229899|
|Principal Investigator:||Jan Hau Lee, MRCPCH(UK)||KK Women's and Children's Hospital|