Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy|
|Study Start Date:||January 2007|
|Study Completion Date:||December 2008|
|Primary Completion Date:||December 2008 (Final data collection date for primary outcome measure)|
Group control with healthy subjects
Healthy subjects without thyroid disease, ocular disease and previous surgery in the orbit or eye used in the study.
Graves' Ophthalmopathy - fibrotic phase
Patients that are clinically inactive (CAS equal or lower than 2). This group will be subdivided in the miogenic and lipogenic groups.
Graves' Ophthalmopathy - active phase
Patients that are clinically active, presenting a CAS of 4 or more points, with or without disthyroid optic neuropathy.
Prospective study with Grave's patients in active and fibrotic disease, myogenic and lipogenic forms, with muscle restriction and without muscle restriction and with or without optic compressive neuropathy. Blood flow was studied with Color Doppler Imaging (CDI) in the following orbital vessels:
- Superior Ophthalmic Vein (main target of the study protocol)
- Retinal Central Vein
- Retinal Central Artery
- Ophthalmic Artery
Please refer to this study by its ClinicalTrials.gov identifier: NCT00697528
|Hospital das Clínicas da Universidade São Paulo|
|São Paulo, Brazil, 05403-000|
|Study Director:||Mário LR Monteiro, Professor||Instituto do Coracao|
|Study Chair:||Joseph E Benabou||Instituto do Coracao|