Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy
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|ClinicalTrials.gov Identifier: NCT00697528|
Recruitment Status : Completed
First Posted : June 16, 2008
Last Update Posted : December 19, 2013
|Condition or disease|
|Graves' Disease Graves' Ophthalmopathy|
Prospective study with Grave's patients in active and fibrotic disease, myogenic and lipogenic forms, with muscle restriction and without muscle restriction and with or without optic compressive neuropathy. Blood flow was studied with Color Doppler Imaging (CDI) in the following orbital vessels:
- Superior Ophthalmic Vein (main target of the study protocol)
- Retinal Central Vein
- Retinal Central Artery
- Ophthalmic Artery
|Study Type :||Observational|
|Actual Enrollment :||66 participants|
|Observational Model:||Case Control|
|Official Title:||Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy|
|Study Start Date :||January 2007|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||December 2008|
Group control with healthy subjects
Healthy subjects without thyroid disease, ocular disease and previous surgery in the orbit or eye used in the study.
Graves' Ophthalmopathy - fibrotic phase
Patients that are clinically inactive (CAS equal or lower than 2). This group will be subdivided in the miogenic and lipogenic groups.
Graves' Ophthalmopathy - active phase
Patients that are clinically active, presenting a CAS of 4 or more points, with or without disthyroid optic neuropathy.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00697528
|Hospital das Clínicas da Universidade São Paulo|
|São Paulo, Brazil, 05403-000|
|Study Director:||Mário LR Monteiro, Professor||Instituto do Coracao|
|Study Chair:||Joseph E Benabou||Instituto do Coracao|