Effects of Sevoflurane and Propofol on Light Flash Evoked Pupillometry
Null hypothesis (HO): There will be no difference in pupillometry readings when using any of the maintenance anesthetic techniques within subjects.
Alternate hypothesis (HA): Pupillometry readings will be affected by a change in the anesthetic technique
Measurement of Pupil Diameter
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Effects of Sevoflurane and Propofol on Light Flash Evoked Pupillometry.|
- We would like to focus on the feasibility of using a monitor which may signal loss of visual function intraoperatively. [ Time Frame: 18 months ] [ Designated as safety issue: No ]
|Study Start Date:||September 2007|
|Study Completion Date:||September 2009|
|Primary Completion Date:||September 2009 (Final data collection date for primary outcome measure)|
Postoperative visual loss resulting from a surgical procedure not performed on the eye is a devastating outcome for the patient and poorly understood by the medical community. It is potentially a preventable complication. Diminished blood supply to the optic nerve, affecting both the anterior or posterior portions of the optic nerve, is the most common cause of postoperative visual loss. Other, less common causes include occlusion of the retinal artery and vein, a retinal embolism and cortical blindness. The incidence of postoperative visual loss increases in patients undergoing cardiopulmonary bypass and prone spine surgery. Although the etiology of post-operative visual loss is unknown, it is thought to be multifactorial, and several potential risk factors have been identified, including degree of low blood pressure, preoperative hematocrit, external compression of the eye, amount of blood loss, prolonged duration of surgical time and increased pressure in the eye associated with positioning. To date studies have focused on the mechanism associated with the visual loss. We would like to focus on the feasibility of using a monitor which may signal loss of visual function intraoperatively.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00695890
|United States, New Jersey|
|Newark, New Jersey, United States, 07101|
|Principal Investigator:||Geordie Grant, MD||Rutgers, The State University of New Jersey|