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Training-induced Cerebral Reorganization in Schizophrenia

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ClinicalTrials.gov Identifier: NCT00695708
Recruitment Status : Completed
First Posted : June 12, 2008
Last Update Posted : April 13, 2010
Sponsor:
Collaborator:
German Research Foundation
Information provided by:
University of Konstanz

Brief Summary:
The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.

Condition or disease Intervention/treatment Phase
Schizophrenia Behavioral: Brain Fitness Program Behavioral: Cogpack Not Applicable

Detailed Description:

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease.

In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing.

The other training involves a variability of cognitive abilities.

Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Official Title: Training-induced Cerebral Reorganization in Schizophrenia
Study Start Date : January 2008
Actual Primary Completion Date : June 2009
Actual Study Completion Date : January 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia
U.S. FDA Resources

Arm Intervention/treatment
Experimental: BFT
20 schizophrenic patients
Behavioral: Brain Fitness Program
Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention
Active Comparator: CP
19 schizophrenic patients
Behavioral: Cogpack
Computer-aided cognitive program for cognitive abilities
No Intervention: HCG
20 healthy age and sex matched subjects



Primary Outcome Measures :
  1. Event related potential MEG, test scores in word fluency and verbal learning tasks [ Time Frame: pre and post intervention ]

Secondary Outcome Measures :
  1. Symptom severity, GAF score [ Time Frame: pre and post intervention ]


Information from the National Library of Medicine

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Ages Eligible for Study:   up to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of schizophrenia and disorders with psychotic features
  • Intact hearing abilities

Exclusion Criteria:

  • Mental retardation
  • Age over 60
  • Insufficient German language knowledge

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00695708


Locations
Germany
University of Konstanz
Konstanz, Baden Württenberg, Germany, 78457
Sponsors and Collaborators
University of Konstanz
German Research Foundation
Investigators
Study Chair: Brigitte Rockstroh, Prof. Dr. University of Konstanz, Department of Psychology

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Rockstroh Brigitte, Prof. Dr., University of Konstanz
ClinicalTrials.gov Identifier: NCT00695708     History of Changes
Other Study ID Numbers: RO 805/14
First Posted: June 12, 2008    Key Record Dates
Last Update Posted: April 13, 2010
Last Verified: June 2008

Keywords provided by University of Konstanz:
schizophrenia
neuroplasticity
sensory gating
cognitive impairment
MEG
Disorders with Psychotic Features

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders