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Training-induced Cerebral Reorganization in Schizophrenia

This study has been completed.
German Research Foundation
Information provided by:
University of Konstanz Identifier:
First received: June 9, 2008
Last updated: April 12, 2010
Last verified: June 2008
The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.

Condition Intervention
Schizophrenia Behavioral: Brain Fitness Program Behavioral: Cogpack

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Official Title: Training-induced Cerebral Reorganization in Schizophrenia

Resource links provided by NLM:

Further study details as provided by University of Konstanz:

Primary Outcome Measures:
  • Event related potential MEG, test scores in word fluency and verbal learning tasks [ Time Frame: pre and post intervention ]

Secondary Outcome Measures:
  • Symptom severity, GAF score [ Time Frame: pre and post intervention ]

Estimated Enrollment: 60
Study Start Date: January 2008
Study Completion Date: January 2010
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: BFT
20 schizophrenic patients
Behavioral: Brain Fitness Program
Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention
Active Comparator: CP
19 schizophrenic patients
Behavioral: Cogpack
Computer-aided cognitive program for cognitive abilities
No Intervention: HCG
20 healthy age and sex matched subjects

Detailed Description:

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease.

In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing.

The other training involves a variability of cognitive abilities.

Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.


Ages Eligible for Study:   up to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Clinical diagnosis of schizophrenia and disorders with psychotic features
  • Intact hearing abilities

Exclusion Criteria:

  • Mental retardation
  • Age over 60
  • Insufficient German language knowledge
  Contacts and Locations
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Please refer to this study by its identifier: NCT00695708

University of Konstanz
Konstanz, Baden Württenberg, Germany, 78457
Sponsors and Collaborators
University of Konstanz
German Research Foundation
Study Chair: Brigitte Rockstroh, Prof. Dr. University of Konstanz, Department of Psychology
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Rockstroh Brigitte, Prof. Dr., University of Konstanz Identifier: NCT00695708     History of Changes
Other Study ID Numbers: RO 805/14
Study First Received: June 9, 2008
Last Updated: April 12, 2010

Keywords provided by University of Konstanz:
sensory gating
cognitive impairment
Disorders with Psychotic Features

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders processed this record on September 21, 2017