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Androgens for Poor Responders in In Vitro Fertilization

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ClinicalTrials.gov Identifier: NCT00693108
Recruitment Status : Completed
First Posted : June 6, 2008
Last Update Posted : June 6, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:
it has been shown that androgens in non human primates may favour follicular growth in the ovaries when animals are treated with gonadotropins which are the hormones used in patients receiving treatment with in vitro fertilization. Therefore, this study investigates the potential usefulness of testosterone treatment preceding gonadotropin administration in in vitro fertilization patients having a previous poor response to gonadotropins alone.

Condition or disease Intervention/treatment Phase
Ovarian Response Drug: Transdermal testosterone Phase 3

Study Design

Study Type : Interventional  (Clinical Trial)
Official Title: Transdermal Testosterone to Improve Ovarian Response to Gonadotropins in Poor Responder IVF Patients With Normal Basal Concentrations of FSH
Study Start Date : September 2006

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: 1
Transdermal testosterone treatment during the five days preceding gonadotropin therapy in IVF cycles
Drug: Transdermal testosterone
No Intervention: 2


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients receiving the second IVF treatment attempt having the first treatment cycle cancelled because of poor ovarian response to gonadotropins

Exclusion Criteria:

  • Previous ovarian surgery
  • Clinical or laboratory profile suggesting premature ovarian failure
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00693108


Locations
Spain
Hospital Clinic
Barcelona, Spain, 08036
Sponsors and Collaborators
Hospital Clinic of Barcelona
More Information

Publications:
ClinicalTrials.gov Identifier: NCT00693108     History of Changes
Other Study ID Numbers: IVFANDROGENS
First Posted: June 6, 2008    Key Record Dates
Last Update Posted: June 6, 2008
Last Verified: June 2008

Keywords provided by Hospital Clinic of Barcelona:
Poor
Response
Ovarian
Stimulation
IVF
Patients

Additional relevant MeSH terms:
Testosterone
Testosterone enanthate
Testosterone undecanoate
Testosterone 17 beta-cypionate
Methyltestosterone
Androgens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Anabolic Agents