Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria (PRiSM)
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|ClinicalTrials.gov Identifier: NCT00692627|
Recruitment Status : Completed
First Posted : June 6, 2008
Last Update Posted : January 22, 2015
acidosis, acute renal failure and acute pulmonary oedema are common, and frequently fatal, manifestations of severe P. falciparum malaria. The course of all three might be ameliorated by optimising a patient's intravenous fluid therapy. The fluid treatment of severe malaria is presently empirical, by defining cardiovascular responses to volume replacement we would provide a physiological basis for resuscitation strategies.
We will use pulse contour cardiac output monitoring (PiCCOTM) to guide the fluid resuscitation of patients admitted to intensive care with severe malaria. With data collected during the patients' admission we hope to:
- Assess the degree of hypovolaemia in adults with severe malaria and its contribution to microcirculatory dysfunction and acidosis.
- To assess the relationships between volume status, haemodynamic parameters and the renal and pulmonary manifestations of severe malaria.
- To assess the utility of central venous pressure measurement as a guide for fluid administration in patients with severe malaria
- To investigate the prognostic and clinical utility of central venous oxygen saturation in severe malaria
In this way we hope to develop a greater understanding of the pathophysiology of haemodynamic derangement in severe malaria. By comparing the PiCCO derived data with simpler clinical parameters, we hope to determine potential fluid resuscitation strategies - relevant for a resource poor setting - whose efficacy could be confirmed in future trials.
|Condition or disease|
|Severe Falciparum Malaria|
|Study Type :||Observational|
|Estimated Enrollment :||80 participants|
|Official Title:||Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria|
|Study Start Date :||July 2008|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||December 2008|
- Metabolic Acidosis [ Time Frame: 48 hours ]
- Acute renal failure [ Time Frame: By discharge ]
- Acute pulmonary oedema [ Time Frame: By discharge ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00692627
|Chittagong Medical College Hospital|
|Study Director:||Arjen Dondorp, MD||Mahidol Oxford Research Unit|