Try our beta test site

Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)

This study is ongoing, but not recruiting participants.
National Center for Research Resources (NCRR)
Information provided by (Responsible Party):
Satish R. Raj, Vanderbilt University Identifier:
First received: June 2, 2008
Last updated: August 15, 2016
Last verified: August 2016
We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects. In this pilot study, we will test the null hypothesis (Ho) that there are no differences in the sleep quality between patients with orthostatic intolerance and healthy control subjects.

Condition Intervention
Postural Tachycardia Syndrome
Orthostatic Intolerance
Sleep Disorders
Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Assessment of Objective Sleep Disturbances in Orthostatic Intolerance Using Actigraphy

Resource links provided by NLM:

Further study details as provided by Vanderbilt University:

Primary Outcome Measures:
  • Sleep Latency [ Time Frame: 1 week ]

Secondary Outcome Measures:
  • Sleep Efficiency [ Time Frame: 1 week ]
  • Wake After Sleep Onset [ Time Frame: 1 week ]

Estimated Enrollment: 100
Study Start Date: June 2008
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients meeting the diagnostic criteria for the Postural Tachycardia Syndrome, a form of Orthostatic Intolerance
Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
Watch to be worn on wrist for 7 days (except in water) that will measure activity/movement.
Other Name: ActiWatch from Minimitter
Healthy control subjects who do not meet the criteria for the Postural Tachycardia Syndrome
Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
Watch to be worn on wrist for 7 days (except in water) that will measure activity/movement.
Other Name: ActiWatch from Minimitter


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients diagnosed with the Postural Tachycardia Syndrome. The criteria include:

  • an increase in heart rate on standing (from supine) of >30 bpm
  • in the setting of symptoms of cerebral hypoperfusion that are worse with standing and better when recumbent
  • the symptoms are daily or almost daily
  • the symptoms are chronic (lasting greater than 6 motnsh)

Inclusion Criteria:

  • Diagnosed with orthostatic intolerance by the Vanderbilt Autonomic Dysfunction Center
  • Control subjects will be free of orthostatic intolerance and other major medical problems, free of medications during the study
  • Age between 18-65 years
  • Male and female subjects are eligible.
  • Able and willing to provide informed consent

Exclusion Criteria:

  • Overt cause for postural tachycardia (such as acute dehydration)
  • Self-report of pregnancy
  • Inability to give, or withdrawal of, informed consent
  • Other factors which in the investigator's opinion would prevent the subject from completing the protocol
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00692471

United States, Tennessee
Vanderbilt University
Nashville, Tennessee, United States, 37232-2195
Sponsors and Collaborators
Satish R. Raj
National Center for Research Resources (NCRR)
Principal Investigator: Satish R Raj, MD MSCI Vanderbilt University
  More Information

Additional Information:
Responsible Party: Satish R. Raj, Assistant Professor of Medicine & Pharmacology, Vanderbilt University Identifier: NCT00692471     History of Changes
Other Study ID Numbers: 080233
K23RR020783 ( US NIH Grant/Contract Award Number )
Study First Received: June 2, 2008
Last Updated: August 15, 2016

Keywords provided by Vanderbilt University:
Orthostatic tachycardia

Additional relevant MeSH terms:
Postural Orthostatic Tachycardia Syndrome
Sleep Wake Disorders
Orthostatic Intolerance
Pathologic Processes
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Primary Dysautonomias
Autonomic Nervous System Diseases processed this record on March 24, 2017