Fluid Balance, Hormones and Urine Proteomics in Nephrotic Syndrome in Childhood
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ClinicalTrials.gov Identifier: NCT00690586 |
Recruitment Status
:
Completed
First Posted
: June 4, 2008
Last Update Posted
: June 8, 2010
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Condition or disease |
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Nephrotic Syndrome |
Nephrotic syndrome represents the association of proteinuria, hypoalbuminemia, oedema and hyperlipidemia. The pathogenesis of the oedemas remains controversial. The "underfill" theory is the traditional explanation where massive proteinuria leads to low plasma albumine and a subsequent decrease in intravascular osmotic pressure leading to edema formations. Because most patients are normotensive and have normal intravascular pressure the "overfill" theory has been proposed suggesting a primary defect in renal sodium handling being responsible for oedema formation.
Ten percent of the children with nephrotic syndrome do not respond to standard steroid treatment and a significant proportion of these patients progress towards end-stage renal failure. At initial presentation it cannot be said if a patient will respond to treatment or not.
The purposes of the sudy:
- To describe changes in the hormones, Aldosterone, Atrial Natriuretic Peptide (ANP), Arginin Vasopressin (AVP), Renin and Angiotensin II in patients with idiopathic nephrotic syndrome and to analyse to what extend the change in these hormones reflected a "underfill" or "overfill" situation.
- To describe changes in the urine concentration of the water channel AQP II and the sodium channel ENaC during the course of nephrotic syndrome.
- To test the hypothesis that urine and plasma proteomics from patients with steroid resistant nephrotic syndrome differs from patients with steroid sensitive nephrotic syndrome.
50 pediatric patients with nephrotic syndrome will be included after informed consent from both parents.
At day 1, 2, 3, 30 and 120 blood samples for hormones will be taken together with creatinin, albumine, Na+, K+, Hgb. An Echocardiography will be performed at day 1 and day 30 to determine v. cava inferior index.
At day 1,30 and 120 urine and plasma will be collected for proteomics and measurement of AQP II and ENaC concentrations.
Further more a clinical examination will be performed at day 1, 2, 3, 30 and 120 and weight, blood pressure and response to treatment will be recorded.
Study Type : | Observational |
Actual Enrollment : | 21 participants |
Observational Model: | Case-Only |
Time Perspective: | Prospective |
Official Title: | Fluid Balance, Hormones and Urine Proteomics in Nephrotic Syndrome in Childhood |
Study Start Date : | December 2007 |
Actual Primary Completion Date : | May 2010 |
Actual Study Completion Date : | May 2010 |


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Ages Eligible for Study: | 1 Year to 15 Years (Child) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Idiopathic Nephrotic syndrome, age below 15 years
Exclusion Criteria:
- Systemic disease e.g. Henoch-Schonleins purpura, Lupus erythematosus, diabetes mellitus
- Age over 15 years
- Treatment with diuretics prior to baseline blood samples

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00690586
Denmark | |
Department of Pediatrics, Aarhus University Hospital, Skejby | |
Aarhus, Aarhus N, Denmark, 8200 |
Study Director: | Søren Rittig, MD | Aarhus University Hospital Skejby |
Responsible Party: | Rene Frydensbjerg Andersen, Aarhus University Hospital |
ClinicalTrials.gov Identifier: | NCT00690586 History of Changes |
Other Study ID Numbers: |
nsdk07-09 |
First Posted: | June 4, 2008 Key Record Dates |
Last Update Posted: | June 8, 2010 |
Last Verified: | June 2008 |
Keywords provided by Aarhus University Hospital:
Nephrotic syndrome Underfill and overfill theory Steroid resistance Urine proteomics |
AVP ANP Angiotensin II Renin and Aldosterone |
Additional relevant MeSH terms:
Syndrome Nephrotic Syndrome Nephrosis Disease Pathologic Processes |
Kidney Diseases Urologic Diseases Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs |