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Force Enhancement of Musculus Quadriceps Femoris During and After Excentric Muscle Activity in Vivo

This study is ongoing, but not recruiting participants.
Information provided by:
German Research Foundation Identifier:
First received: May 30, 2008
Last updated: November 27, 2009
Last verified: November 2009
Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.

Condition Intervention
Muscle Quadriceps Femoris
Other: muscle activation

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Force Enhancement of m. Quadriceps Femoris During and After Excentric Muscle Activity in Vivo by Maximal and Sub-maximal Deliberately Activation.

Further study details as provided by German Research Foundation:

Primary Outcome Measures:
  • Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend). [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation [ Time Frame: 12 months ] [ Designated as safety issue: No ]
  • Correlation between typ of muscle fiber and force enhancement in vivo [ Time Frame: 12 months ] [ Designated as safety issue: No ]
  • Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 60
Study Start Date: October 2008
Estimated Study Completion Date: October 2010
Estimated Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Test Group Other: muscle activation
activation of the muscle quadriceps femoris

Detailed Description:
The research proposal is resubmitted with no amendments made regarding content.

Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
males without previous muscular or neurophysiological diseases at an age between 20 and 40 years

Inclusion Criteria:

  • Males without previous muscular or neurophysiological diseases
  • Age between 20 and 40 years

Exclusion Criteria:

  • Previous muscular or neurophysiological diseases
  Contacts and Locations
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Please refer to this study by its identifier: NCT00690547

Technical University of Munich, Department of Biomechanics in Sports
Munich, Germany, 80809
Sponsors and Collaborators
German Research Foundation
Principal Investigator: Ansgar Schmirtz, Prof. Dr. Technical University of Munich, Department of Biomechanics in Sports
  More Information

Responsible Party: Prof. Dr. Ansgar Schwirtz, Technical University of Munich, Department of Biomechanics in Sports Identifier: NCT00690547     History of Changes
Other Study ID Numbers: DFG27112007 
Study First Received: May 30, 2008
Last Updated: November 27, 2009
Health Authority: Germany: German Research Foundation (DFG)

Keywords provided by German Research Foundation:
Extension processed this record on January 14, 2017