Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection
This study is currently recruiting participants.
(see Contacts and Locations)
Verified April 2016 by Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor:
Kaohsiung Medical University Chung-Ho Memorial Hospital
Collaborator:
Centers for Disease Control and Prevention
Information provided by (Responsible Party):
Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00688389
First received: May 28, 2008
Last updated: June 22, 2016
Last verified: April 2016
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Purpose
The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
| Condition | Intervention |
|---|---|
|
Dengue Fever |
Other: case/control |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control |
| Official Title: | Follow-up the Health Condition , Investigation of the Immuno-regulation , and the Study for Interaction of Viral Hepatitis--- Among Patients With or After Dengue Fever Infection |
Resource links provided by NLM:
Genetic and Rare Diseases Information Center resources:
Dengue Fever
Hemorrhagic Fever
Viral Hemorrhagic Fever
U.S. FDA Resources
Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:
Primary Outcome Measures:
- 檢查肝臟、腎臟及其他生化功能，並分析宿主免疫調控及血小板變化機致 [ Time Frame: 2007/7/1 ] [ Designated as safety issue: Yes ]抽血20 c.c 檢查肝臟、腎臟及其他生化功能，並分析宿主免疫調控及血小板變化機致
Biospecimen Retention: Samples With DNA
blood samples
| Estimated Enrollment: | 700 |
| Study Start Date: | July 2007 |
| Estimated Study Completion Date: | December 2017 |
| Estimated Primary Completion Date: | December 2017 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| healthy |
Other: case/control
case: infected dengue fever people control:healthy people
|
| DF |
Other: case/control
case: infected dengue fever people control:healthy people
|
| DHF |
Other: case/control
case: infected dengue fever people control:healthy people
|
Detailed Description:
Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
Eligibility| Ages Eligible for Study: | Child, Adult, Senior |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
The samples are obtained from the Kaohsiung Medical University Chung-Ho Memorial Hospital in Kaohsiung, Taiwan.
Criteria
Inclusion Criteria:
- Clinical diagnosis of Dengue fever
Exclusion Criteria:
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00688389
Please refer to this study by its ClinicalTrials.gov identifier: NCT00688389
Contacts
| Contact: Jih-Jin Tsai, MD | 886-7-312-1101 ext 5677 | jijits@cc.kmu.edu.tw |
Locations
| Taiwan | |
| Kaoshing Medical University Chung-Ho Memorial Hospital | Recruiting |
| Kaoshiung, Taiwan | |
| Contact: Jih-Jin Tsai, MD 886-7-312-1101 ext 5677 jijits@cc.kmu.edu.tw | |
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Centers for Disease Control and Prevention
More Information
| Responsible Party: | Kaohsiung Medical University Chung-Ho Memorial Hospital |
| ClinicalTrials.gov Identifier: | NCT00688389 History of Changes |
| Other Study ID Numbers: | KMUH-IRB-960195_1 CB9615 |
| Study First Received: | May 28, 2008 |
| Last Updated: | June 22, 2016 |
| Health Authority: | Taiwan: Institutional Review Board |
Keywords provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:
|
Dengue fever, CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), (Nod)-like receptors (NLRs) |
Additional relevant MeSH terms:
|
Fever Dengue Body Temperature Changes Signs and Symptoms Arbovirus Infections |
Virus Diseases Flavivirus Infections Flaviviridae Infections RNA Virus Infections Hemorrhagic Fevers, Viral |
ClinicalTrials.gov processed this record on September 23, 2016