Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2016 by Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor:
Collaborator:
Centers for Disease Control and Prevention
Information provided by (Responsible Party):
Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00688389
First received: May 28, 2008
Last updated: June 22, 2016
Last verified: April 2016
  Purpose
The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.

Condition Intervention
Dengue Fever
Other: case/control

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Follow-up the Health Condition , Investigation of the Immuno-regulation , and the Study for Interaction of Viral Hepatitis--- Among Patients With or After Dengue Fever Infection

Resource links provided by NLM:


Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • 檢查肝臟、腎臟及其他生化功能,並分析宿主免疫調控及血小板變化機致 [ Time Frame: 2007/7/1 ] [ Designated as safety issue: Yes ]
    抽血20 c.c 檢查肝臟、腎臟及其他生化功能,並分析宿主免疫調控及血小板變化機致


Biospecimen Retention:   Samples With DNA
blood samples

Estimated Enrollment: 700
Study Start Date: July 2007
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
healthy Other: case/control
case: infected dengue fever people control:healthy people
DF Other: case/control
case: infected dengue fever people control:healthy people
DHF Other: case/control
case: infected dengue fever people control:healthy people

Detailed Description:
Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
  Eligibility

Ages Eligible for Study:   Child, Adult, Senior
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The samples are obtained from the Kaohsiung Medical University Chung-Ho Memorial Hospital in Kaohsiung, Taiwan.
Criteria

Inclusion Criteria:

  • Clinical diagnosis of Dengue fever

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00688389

Contacts
Contact: Jih-Jin Tsai, MD 886-7-312-1101 ext 5677 jijits@cc.kmu.edu.tw

Locations
Taiwan
Kaoshing Medical University Chung-Ho Memorial Hospital Recruiting
Kaoshiung, Taiwan
Contact: Jih-Jin Tsai, MD    886-7-312-1101 ext 5677    jijits@cc.kmu.edu.tw   
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Centers for Disease Control and Prevention
  More Information

Responsible Party: Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier: NCT00688389     History of Changes
Other Study ID Numbers: KMUH-IRB-960195_1  CB9615 
Study First Received: May 28, 2008
Last Updated: June 22, 2016
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:
Dengue fever, CLEC5A, Mannose receptor, DC-SIGN, NALP,
decoy receptor 3 (DcR3), Toll-like receptors(TLRs),
(Nod)-like receptors (NLRs)

Additional relevant MeSH terms:
Fever
Dengue
Body Temperature Changes
Signs and Symptoms
Arbovirus Infections
Virus Diseases
Flavivirus Infections
Flaviviridae Infections
RNA Virus Infections
Hemorrhagic Fevers, Viral

ClinicalTrials.gov processed this record on August 30, 2016