Sleepiness and Brain Function: The Effect of Armodafinil in Shift Work Sleep Disorder

This study has been completed.
Information provided by:
Henry Ford Health System Identifier:
First received: May 28, 2008
Last updated: March 30, 2010
Last verified: March 2010
The investigators hypothesize that in patients with shift work sleep disorder, armodafinil will specifically increase brain activity in the frontal cortex parallel with improvements in deficits of fundamental mechanisms of attention.

Shift Work Sleep Disorder

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Magnetoencephalographic Imaging of Sleepiness: The Effect of Armodafinil in Shift Work Sleep Disorder

Resource links provided by NLM:

Further study details as provided by Henry Ford Health System:

Enrollment: 24
Study Start Date: February 2008
Study Completion Date: March 2010
Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Individuals with shift work sleep disorder
Healthy night shift workers without shift work sleep disorder

Detailed Description:
The current protocol will utilize a paradigm which is well suited to examine frontal attentional neuronal mechanisms by eliciting event related potential components known to reflect automatic stimulus detection as well as involuntary and voluntary attentional processes. The that end the proposed research has two specific aims. 1) Identify what areas of the frontal lobe and corresponding cognitive functions are impacted by excessive sleepiness in shift work sleep disorder and 2) identify specific brain areas affected by armodafinil and their role in improvement of fundamental attentional processes using a complex cognitive task targeting attentional control.

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Study population must be healthy night shift workers with a diagnosis of shift work sleep disorder.

Inclusion Criteria:

  • Night shift workers with and without shift work sleep disorder.

Exclusion Criteria:

  • Secondary condition to shift work sleep disorder.
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Please refer to this study by its identifier: NCT00688142

United States, Michigan
Henry Ford Hospital Sleep Disorders & Research Center
Detroit, Michigan, United States, 48202
Sponsors and Collaborators
Henry Ford Health System
Principal Investigator: Christopher Drake, Ph.D. Henry Ford Hospital Sleep Disorders & Research Center
  More Information

Responsible Party: Christopher Drake, Ph.D., Henry Ford Health System Identifier: NCT00688142     History of Changes
Other Study ID Numbers: C10953/6079/ES/US 
Study First Received: May 28, 2008
Last Updated: March 30, 2010
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Sleep Disorders
Sleep Disorders, Circadian Rhythm
Chronobiology Disorders
Mental Disorders
Nervous System Diseases
Neurologic Manifestations
Occupational Diseases
Signs and Symptoms
Central Nervous System Agents
Central Nervous System Stimulants
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
Wakefulness-Promoting Agents processed this record on April 27, 2016