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Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools (proto nage)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2008 by Laval University.
Recruitment status was:  Recruiting
Information provided by:
Laval University Identifier:
First received: May 26, 2008
Last updated: December 18, 2008
Last verified: May 2008

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

  1. to compare the prevalence of asthma in swimmers and control subjects
  2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
  3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Asthma Airway Hyperresponsiveness

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools

Further study details as provided by Laval University:

Primary Outcome Measures:
  • Asthma and airway hyperreactivity prevalence in swimmers [ Time Frame: 3 measurements in the year ]

Secondary Outcome Measures:
  • Airway inflammation and remodeling in swimmers [ Time Frame: 3 measurements in the year and a bronchial biopsy ]

Biospecimen Retention:   Samples With DNA
Serum, plasma, bronchial biopsies

Estimated Enrollment: 100
Study Start Date: March 2007
Estimated Study Completion Date: May 2009
Estimated Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Swimmers without AHR
Swimmers with asymptomatic AHR
Swimmers with symptomatic AHR and use only of beta-2 adrenargic
Swimmers with asthma and inhaled corticosteroids
Healthy Subjects
Healthy subjects with AHR
Healthy subjects with symptomatic AHR (asthma) but without treatment


Ages Eligible for Study:   14 Years to 35 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Swimmers from Quebec swimming school and universities Control from université Laval or secondary School

Inclusion Criteria:

  • 14 to 35 years old
  • To swim at least 10h per week
  • For control subjects, non-competitive healthy subjects

Exclusion Criteria:

  • any disease that may interfere with the tests for the controls
  • Triathletes are excluded
  • Smokers
  • Obese or with a BMI more than 29
  • Former athletes (control group)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00686452

Contact: Valérie BOUGAULT, PhD 418-656-8711 ext 1507
Contact: Louis-Philippe BOULET, MD 418-656-4747

Canada, Quebec
Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval Recruiting
Québec, Quebec, Canada, G1V4G5
Contact: Valerie BOUGAULT, PhD    418-656-8711 ext 1507   
Contact: Louis-Philippe BOULET, MD   
Principal Investigator: Louis-Philippe BOULET, MD         
Sponsors and Collaborators
Laval University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Dr Louis-Philippe BOULET, MD, Hôpital Laval Identifier: NCT00686452     History of Changes
Other Study ID Numbers: CER20159
Study First Received: May 26, 2008
Last Updated: December 18, 2008

Keywords provided by Laval University:
Airway hyperresponsiveness
Airway inflammation
Airway remodelling

Additional relevant MeSH terms:
Respiratory Hypersensitivity
Respiratory Tract Diseases
Hypersensitivity, Immediate
Immune System Diseases processed this record on August 18, 2017