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Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO)

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ClinicalTrials.gov Identifier: NCT00686309
Recruitment Status : Unknown
Verified August 2009 by Ziv Hospital.
Recruitment status was:  Not yet recruiting
First Posted : May 29, 2008
Last Update Posted : August 18, 2009
Sponsor:
Information provided by:

Study Description
Brief Summary:
Asthma is a major health problem worldwide. The measurement of fractional exhaled nitric oxide (FENO) has been established as a valuable non invasive and simple tool in the diagnosis of asthma and may also act as a useful surrogate inflammatory marker on which to base treatment decisions in asthma management algorithms. The measurement is useful also in other respiratory diseases. Current methods of measuring FENO include on line measurements by heavy duty expensive analyzers which are not widely and easily available. Off line measurements of breath samples which can be analysed later may be a simple solution. We hypothesize tha toff line measurements of NO will be as reliable and valid as those measured on-line

Condition or disease
Asthma Primary Ciliary Dyskinesia

Study Design

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Comparison of On-line and Off-line Measurements of Exhaled NO
Study Start Date : July 2010
Estimated Primary Completion Date : July 2011
Estimated Study Completion Date : July 2011


Groups and Cohorts


Outcome Measures

Primary Outcome Measures :
  1. Off line measurement of exhaled NO [ Time Frame: Two types of breathing in the same day ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
General population bth healthy and with respiratory illness such as asthma, COPD, PCD, Rhinitis
Criteria

Inclusion Criteria:

  • Volunteer to participate
  • Filed a short health questionnaire

Exclusion Criteria:

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00686309


Contacts
Contact: Israel Amirav, MD 972-4-682-8712 amirav@012.net.il

Locations
Israel
Pediatric Department, Ziv Medical Center Not yet recruiting
Safed, Israel
Contact: Israel Amirav, MD    972-4-682-8712    amirav@012.net.il   
Principal Investigator: Israel Amirav, MD         
Sponsors and Collaborators
Ziv Hospital
More Information

Responsible Party: Israel Amirav, Ziv Medical center
ClinicalTrials.gov Identifier: NCT00686309     History of Changes
Other Study ID Numbers: HP8-295-R
First Posted: May 29, 2008    Key Record Dates
Last Update Posted: August 18, 2009
Last Verified: August 2009

Keywords provided by Ziv Hospital:
exhaled NO
off line
on line
comparison
Bland altman method

Additional relevant MeSH terms:
Dyskinesias
Ciliary Motility Disorders
Kartagener Syndrome
Movement Disorders
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
Ciliopathies
Abnormalities, Multiple
Congenital Abnormalities
Genetic Diseases, Inborn
Bronchiectasis
Bronchial Diseases
Respiratory System Abnormalities
Dextrocardia
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Situs Inversus