Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00686309
Recruitment Status : Unknown
Verified August 2009 by Ziv Hospital.
Recruitment status was:  Not yet recruiting
First Posted : May 29, 2008
Last Update Posted : August 18, 2009
Information provided by:
Ziv Hospital

Brief Summary:
Asthma is a major health problem worldwide. The measurement of fractional exhaled nitric oxide (FENO) has been established as a valuable non invasive and simple tool in the diagnosis of asthma and may also act as a useful surrogate inflammatory marker on which to base treatment decisions in asthma management algorithms. The measurement is useful also in other respiratory diseases. Current methods of measuring FENO include on line measurements by heavy duty expensive analyzers which are not widely and easily available. Off line measurements of breath samples which can be analysed later may be a simple solution. We hypothesize tha toff line measurements of NO will be as reliable and valid as those measured on-line

Condition or disease
Asthma Primary Ciliary Dyskinesia

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Comparison of On-line and Off-line Measurements of Exhaled NO
Study Start Date : July 2010
Estimated Primary Completion Date : July 2011
Estimated Study Completion Date : July 2011

Primary Outcome Measures :
  1. Off line measurement of exhaled NO [ Time Frame: Two types of breathing in the same day ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
General population bth healthy and with respiratory illness such as asthma, COPD, PCD, Rhinitis

Inclusion Criteria:

  • Volunteer to participate
  • Filed a short health questionnaire

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00686309

Contact: Israel Amirav, MD 972-4-682-8712

Pediatric Department, Ziv Medical Center Not yet recruiting
Safed, Israel
Contact: Israel Amirav, MD    972-4-682-8712   
Principal Investigator: Israel Amirav, MD         
Sponsors and Collaborators
Ziv Hospital

Responsible Party: Israel Amirav, Ziv Medical center Identifier: NCT00686309     History of Changes
Other Study ID Numbers: HP8-295-R
First Posted: May 29, 2008    Key Record Dates
Last Update Posted: August 18, 2009
Last Verified: August 2009

Keywords provided by Ziv Hospital:
exhaled NO
off line
on line
Bland altman method

Additional relevant MeSH terms:
Ciliary Motility Disorders
Kartagener Syndrome
Movement Disorders
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
Abnormalities, Multiple
Congenital Abnormalities
Genetic Diseases, Inborn
Bronchial Diseases
Respiratory System Abnormalities
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Situs Inversus