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Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients (MOSAR-04)

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ClinicalTrials.gov Identifier: NCT00685867
Recruitment Status : Completed
First Posted : May 29, 2008
Last Update Posted : August 21, 2012
Sponsor:
Collaborator:
European Commission
Information provided by (Responsible Party):
Stephen Harbarth, University Hospital, Geneva

Brief Summary:

The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, Greece and Israel).

The primary objective is to determine the effect of an early MRSA detection & decolonization & isolation strategy compared to an enhanced standard control strategy on healthcare-associated MRSA isolation rates among surgical patients at risk of MRSA carriage, who are hospitalized for at least 24 hours.


Condition or disease Intervention/treatment Phase
MRSA Infection Other: Rapid molecular MRSA test Behavioral: Hand hygiene promotion Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 126750 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: An Interventional Study to Evaluate the Impact of Two Innovative Strategies in Preventing Nosocomial MRSA Infection in Surgical Patients
Study Start Date : May 2008
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: MRSA
U.S. FDA Resources

Arm Intervention/treatment
Experimental: 1
Rapid detection
Other: Rapid molecular MRSA test
PCR-based rapid screening for MRSA carriage
2
Enhanced infection control
Behavioral: Hand hygiene promotion
  • Promotion and monitoring of hand hygiene, with special emphasis on alcohol-based hand rubs and feedback of hand hygiene compliance
  • Standard precautions (e.g. use of gloves for contacts with wounds and body fluids)
  • Isolation precautions according to the hospitals' capacity and strategy
  • Additional basic infection control interventions (if necessary)



Primary Outcome Measures :
  1. Nosocomial MRSA isolation rate (expressed as the monthly rate of MRSA in clinical isolates divided by the number of susceptible patients per hundred) [ Time Frame: Monthly ]

Secondary Outcome Measures :
  1. Nosocomial MRSA infection rate (= number of nosocomial MRSA infections per 100 admissions) [ Time Frame: Monthly ]


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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Surgical patients with LOS>24h

Exclusion Criteria:

  • Surgical patients with LOS<24h

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00685867


Locations
Switzerland
Geneva University Hospitals
Geneva, Switzerland, 1211
Sponsors and Collaborators
University Hospital, Geneva
European Commission

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Stephen Harbarth, Professor, University Hospital, Geneva
ClinicalTrials.gov Identifier: NCT00685867     History of Changes
Other Study ID Numbers: LSHP-CT-037940
First Posted: May 29, 2008    Key Record Dates
Last Update Posted: August 21, 2012
Last Verified: August 2012

Keywords provided by Stephen Harbarth, University Hospital, Geneva:
Staphylococcus aureus
Resistance
Prevention

Additional relevant MeSH terms:
Infection
Communicable Diseases
Staphylococcal Infections
Gram-Positive Bacterial Infections
Bacterial Infections