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Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD) (TDA/H)

This study has been terminated.
(Difficulties in the organisation)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00684931
First Posted: May 28, 2008
Last Update Posted: June 23, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Bordeaux
  Purpose
The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.

Condition Intervention
Attention Deficit Disorder With Hyperactivity Other: Imaging

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Alterations of Fronto-Cerebello-Frontal Loops in Attention Deficit Hyperactivity Disorder (ADHD) : A Study Using Magnetic Resonance Imaging (MRI)

Resource links provided by NLM:


Further study details as provided by University Hospital, Bordeaux:

Primary Outcome Measures:
  • Fractional anisotropy coefficient if fronto-cerebello-frontal loops. [ Time Frame: visite 1 ]

Enrollment: 19
Study Start Date: February 2008
Study Completion Date: July 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
patients with Attention Deficit Disorder with or without Hyperactivity
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)
Sham Comparator: 2
healthy volunteer without Attention Deficit Hyperactivity Disorder
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)

Detailed Description:
ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Patient with ADHD :

  • Diagnosis of ADHD
  • 18 - 35 years old

Healthy volunteer :

  • 18 - 35 years old
  • no ADHD diagnosed

Exclusion Criteria:

  • Associated neurological or psychiatric pathologies
  • Pregnant woman
  • MRI counter indication
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00684931


Locations
France
Charles Perrens Hospital
Bordeaux, France, 33000
University Hospital Bordeaux
Bordeaux, France, 33076
Sponsors and Collaborators
University Hospital, Bordeaux
Investigators
Principal Investigator: Manuel BOUVARD, MD Charles Perrens Hospital
  More Information

Responsible Party: Jean-Pierre LEROY / Clinical Research and Innovation Director, University Hospital, Bordeaux
ClinicalTrials.gov Identifier: NCT00684931     History of Changes
Other Study ID Numbers: CHUBX 2007/21
First Submitted: May 22, 2008
First Posted: May 28, 2008
Last Update Posted: June 23, 2009
Last Verified: June 2009

Keywords provided by University Hospital, Bordeaux:
Attention
Deficit
Disorder
Hyperactivity
cerebellum
alteration
fronto-cerebello-frontal loops

Additional relevant MeSH terms:
Disease
Attention Deficit Disorder with Hyperactivity
Hyperkinesis
Pathologic Processes
Attention Deficit and Disruptive Behavior Disorders
Neurodevelopmental Disorders
Mental Disorders
Dyskinesias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms