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Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD) (TDA/H)

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ClinicalTrials.gov Identifier: NCT00684931
Recruitment Status : Terminated (Difficulties in the organisation)
First Posted : May 28, 2008
Last Update Posted : June 23, 2009
Information provided by:
University Hospital, Bordeaux

Brief Summary:
The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.

Condition or disease Intervention/treatment
Attention Deficit Disorder With Hyperactivity Other: Imaging

Detailed Description:
ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 19 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Alterations of Fronto-Cerebello-Frontal Loops in Attention Deficit Hyperactivity Disorder (ADHD) : A Study Using Magnetic Resonance Imaging (MRI)
Study Start Date : February 2008
Primary Completion Date : February 2008
Study Completion Date : July 2008

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U.S. FDA Resources

Arm Intervention/treatment
Experimental: 1
patients with Attention Deficit Disorder with or without Hyperactivity
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)
Sham Comparator: 2
healthy volunteer without Attention Deficit Hyperactivity Disorder
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)

Primary Outcome Measures :
  1. Fractional anisotropy coefficient if fronto-cerebello-frontal loops. [ Time Frame: visite 1 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

Patient with ADHD :

  • Diagnosis of ADHD
  • 18 - 35 years old

Healthy volunteer :

  • 18 - 35 years old
  • no ADHD diagnosed

Exclusion Criteria:

  • Associated neurological or psychiatric pathologies
  • Pregnant woman
  • MRI counter indication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00684931

Charles Perrens Hospital
Bordeaux, France, 33000
University Hospital Bordeaux
Bordeaux, France, 33076
Sponsors and Collaborators
University Hospital, Bordeaux
Principal Investigator: Manuel BOUVARD, MD Charles Perrens Hospital

Responsible Party: Jean-Pierre LEROY / Clinical Research and Innovation Director, University Hospital, Bordeaux
ClinicalTrials.gov Identifier: NCT00684931     History of Changes
Other Study ID Numbers: CHUBX 2007/21
First Posted: May 28, 2008    Key Record Dates
Last Update Posted: June 23, 2009
Last Verified: June 2009

Keywords provided by University Hospital, Bordeaux:
fronto-cerebello-frontal loops

Additional relevant MeSH terms:
Attention Deficit Disorder with Hyperactivity
Pathologic Processes
Attention Deficit and Disruptive Behavior Disorders
Neurodevelopmental Disorders
Mental Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms