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Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD) (TDA/H)

This study has been terminated.
(Difficulties in the organisation)
Information provided by:
University Hospital, Bordeaux Identifier:
First received: May 22, 2008
Last updated: June 22, 2009
Last verified: June 2009
The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.

Condition Intervention
Attention Deficit Disorder With Hyperactivity Other: Imaging

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Alterations of Fronto-Cerebello-Frontal Loops in Attention Deficit Hyperactivity Disorder (ADHD) : A Study Using Magnetic Resonance Imaging (MRI)

Resource links provided by NLM:

Further study details as provided by University Hospital, Bordeaux:

Primary Outcome Measures:
  • Fractional anisotropy coefficient if fronto-cerebello-frontal loops. [ Time Frame: visite 1 ]

Enrollment: 19
Study Start Date: February 2008
Study Completion Date: July 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
patients with Attention Deficit Disorder with or without Hyperactivity
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)
Sham Comparator: 2
healthy volunteer without Attention Deficit Hyperactivity Disorder
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)

Detailed Description:
ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.

Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

Patient with ADHD :

  • Diagnosis of ADHD
  • 18 - 35 years old

Healthy volunteer :

  • 18 - 35 years old
  • no ADHD diagnosed

Exclusion Criteria:

  • Associated neurological or psychiatric pathologies
  • Pregnant woman
  • MRI counter indication
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00684931

Charles Perrens Hospital
Bordeaux, France, 33000
University Hospital Bordeaux
Bordeaux, France, 33076
Sponsors and Collaborators
University Hospital, Bordeaux
Principal Investigator: Manuel BOUVARD, MD Charles Perrens Hospital
  More Information

Responsible Party: Jean-Pierre LEROY / Clinical Research and Innovation Director, University Hospital, Bordeaux Identifier: NCT00684931     History of Changes
Other Study ID Numbers: CHUBX 2007/21
Study First Received: May 22, 2008
Last Updated: June 22, 2009

Keywords provided by University Hospital, Bordeaux:
fronto-cerebello-frontal loops

Additional relevant MeSH terms:
Attention Deficit Disorder with Hyperactivity
Pathologic Processes
Attention Deficit and Disruptive Behavior Disorders
Neurodevelopmental Disorders
Mental Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on August 16, 2017