Evaluation of a Closed-Loop Control System for Administering Patient-Specific Anesthesia
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Numerous efforts have focused on the development of closed-loop systems to control anesthesia using the electrical activity of the brain (EEG) and EEG-based parameters as surrogate measures of anesthetic depth. New systems have been recently developed to considerably improve anesthetic control using model-based, patient-adaptive methods. The purpose of this study is to evaluate the clinical efficacy of a new intelligent software, ReinLoop, in delivering closed-loop, patient-specific hypnosis.
Condition or disease
Device: ReinLoop control software for patient-specific induction and maintenance of anesthesiaDrug: Propofol
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Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
18-45 years of age
Body mass index (BMI) lower or equal to 25 m2/kg
Subjects must be able to comprehend spoken and written English
Any type of psychiatric, neurological, or neuromuscular disorder
History of smoking
Alcohol consumption which exceeds 2 drinks per day and /or drug abuse. Volunteers will be asked the question: How many drinks are you drinking on your typical day?
Allergy to study medication (propofol), soy, or egg proteins.
History of drug abuse
Chronic or acute use of opioids, or other medications affecting the CNS