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Zinc to Treat Tinnitus

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2009 by University of Iowa.
Recruitment status was:  Recruiting
Tinnitus Research Initiative
Information provided by:
University of Iowa Identifier:
First received: May 21, 2008
Last updated: February 13, 2009
Last verified: February 2009
There is widespread belief and some evidence to indicate that zinc can successfully treat tinnitus. Zinc deficiency is more likely to occur in the elderly . The primary objective of this study is to establish the effectiveness of zinc for the treatment of tinnitus in individuals 60 years of age and older. Subjects will be randomly assigned to either receive zinc daily or a placebo. After 4 months and a 1-month wash-out, the subjects will be crossed over to the other group.

Condition Intervention Phase
Tinnitus Dietary Supplement: Zinc sulfate Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Zinc to Treat Tinnitus in the Elderly

Resource links provided by NLM:

Further study details as provided by University of Iowa:

Primary Outcome Measures:
  • Tinnitus loudness and annoyance [ Time Frame: 10 months ]

Secondary Outcome Measures:
  • Tinnitus handicap [ Time Frame: 10 months ]

Estimated Enrollment: 200
Study Start Date: January 2008
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Zinc first, then placebo
Dietary Supplement: Zinc sulfate
Zinc sulfate taken once daily
Experimental: 2
Placebo first, then zinc
Dietary Supplement: Zinc sulfate
Zinc sulfate taken once daily


Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 60 years of age or older
  • Tinnitus for 6 months or more
  • Normal copper levels
  • Be generally healthy

Exclusion Criteria:

  • Have a treatable otological disorder
  • Involved in litigation
  • Have or are suspected of having a serious psychiatric problem
  • Involved in other treatments for tinnitus
  • Are taking drugs which might interact with zinc and result in tinnitus
  • Have copper deficiency
  • Have Zinc levels above normal
  • Are cognitively impaired.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00683644

Contact: Anne Gehringer 319-353-8760

United States, Iowa
University of Iowa Recruiting
Iowa City, Iowa, United States, 52242
Principal Investigator: Richard S. Tyler, Ph.D.         
Sponsors and Collaborators
University of Iowa
Tinnitus Research Initiative
Principal Investigator: Richard S. Tyler, Ph.D. University of Iowa
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Richard S. Tyler, Ph.D., University of Iowa Identifier: NCT00683644     History of Changes
Other Study ID Numbers: TRI Grant RT 06 10
Study First Received: May 21, 2008
Last Updated: February 13, 2009

Additional relevant MeSH terms:
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Zinc Sulfate
Trace Elements
Growth Substances
Physiological Effects of Drugs
Dermatologic Agents processed this record on September 20, 2017