Hemodynamic Measurements During Liver Transplantation (OLT)
The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Comparing Different Methods For Measurement of Cardiac Output During Orthotopic Liver Transplantation|
- Agreement between cardiac output measurements obtained with PAC, Vigileo and LiDCO [ Time Frame: Specific phases of liver transplantation surgery ] [ Designated as safety issue: No ]
|Study Start Date:||July 2007|
|Study Completion Date:||March 2010|
|Primary Completion Date:||January 2009 (Final data collection date for primary outcome measure)|
Pulmonary artery catheter (PAC)is considered the gold standard in monitoring of heart function during orthotopic liver transplantation (OLT). Placement of PAC is very invasive (it passes thorough the heart chambers and into the pulmonary artery) and its benefits on the outcomes have not been proven. This study compares two newer FDA approved much less invasive devices to the PAC. The two new devices assess the heart function based either on the peripheral arterial waveform alone (Vigileo, Edwards Lifesciences)or the combination of peripheral arterial waveform and chemical indicator dilution (LiDCO, Cambridge, UK).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00682110
|United States, Missouri|
|Washington University School of Medicine|
|St. Louis, Missouri, United States, 63110|
|Principal Investigator:||Ivan Kangrga, MD, PhD||Washington University School of Medicine|