Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome
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ClinicalTrials.gov Identifier: NCT00682084 |
Recruitment Status
:
Terminated
(Recruitment problems)
First Posted
: May 22, 2008
Last Update Posted
: December 22, 2017
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Condition or disease | Intervention/treatment |
---|---|
Cushing's Syndrome Insulin Resistance | Procedure: Surgery |
Study Type : | Observational |
Actual Enrollment : | 1 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome Before and After Surgical Treatment |
Study Start Date : | April 2008 |
Actual Primary Completion Date : | November 2016 |
Actual Study Completion Date : | November 2016 |

Group/Cohort | Intervention/treatment |
---|---|
1
Patients recently diagnosed with Cushing's syndrome
|
Procedure: Surgery
Surgical removal of either a pituitary or ectopic ACTH producing tumor or an adrenal tumor
|
- Insulin sensitivity [ Time Frame: Before and after treatment ]
- Glucose tolerance, QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism. [ Time Frame: Before and after treatment ]
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years to 70 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Written consent
- Age between 18 and 70
- Diagnosed with Cushing's syndrome
Exclusion Criteria:
- Suspected malignancy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00682084
Denmark | |
Department of Endocrinology | |
Aarhus C, Aarhus, Denmark, 8000 |
Principal Investigator: | Jens Otto L. Jørgensen, Professor MD | Aarhus University Hospital, Department of Endocrinology |
Responsible Party: | University of Aarhus |
ClinicalTrials.gov Identifier: | NCT00682084 History of Changes |
Other Study ID Numbers: |
MM-ISC-20070131 |
First Posted: | May 22, 2008 Key Record Dates |
Last Update Posted: | December 22, 2017 |
Last Verified: | December 2014 |
Keywords provided by University of Aarhus:
Cushing's syndrome Glucose tolerance Insulin sensitivity Substrate metabolism Body composition |
Additional relevant MeSH terms:
Syndrome Hypersensitivity Insulin Resistance Cushing Syndrome Disease Pathologic Processes Immune System Diseases Hyperinsulinism |
Glucose Metabolism Disorders Metabolic Diseases Adrenocortical Hyperfunction Adrenal Gland Diseases Endocrine System Diseases Insulin Hypoglycemic Agents Physiological Effects of Drugs |