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Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2014 by University of Aarhus.
Recruitment status was:  Recruiting
Aarhus University Hospital
Information provided by (Responsible Party):
University of Aarhus Identifier:
First received: May 20, 2008
Last updated: December 2, 2014
Last verified: December 2014
The purpose of this study is to investigate the effect og chronic elevated levels of cortisol on metabolism and insulin sensitivity.

Condition Intervention
Cushing's Syndrome
Insulin Resistance
Procedure: Surgery

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome Before and After Surgical Treatment

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Insulin sensitivity [ Time Frame: Before and after treatment ]

Secondary Outcome Measures:
  • Glucose tolerance, QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism. [ Time Frame: Before and after treatment ]

Biospecimen Retention:   Samples Without DNA
Whole blood, serum, muscle samples, fat samples

Estimated Enrollment: 10
Study Start Date: April 2008
Estimated Study Completion Date: January 2016
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients recently diagnosed with Cushing's syndrome
Procedure: Surgery
Surgical removal of either a pituitary or ectopic ACTH producing tumor or an adrenal tumor


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients recently diagnosed with Cushing's syndrome, recruited from the clinic.

Inclusion Criteria:

  • Written consent
  • Age between 18 and 70
  • Diagnosed with Cushing's syndrome

Exclusion Criteria:

  • Suspected malignancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT00682084

Contact: Jens Otto L. Jørgensen, Professor MD 89492025 ext +45
Contact: Michael Madsen, MD 89492171 ext +45

Department of Endocrinology Recruiting
Aarhus C, Aarhus, Denmark, 8000
Principal Investigator: Jens Otto L. Jørgensen, Professor MD         
Sub-Investigator: Michael Madsen, MD         
Sponsors and Collaborators
University of Aarhus
Aarhus University Hospital
Principal Investigator: Jens Otto L. Jørgensen, Professor MD Aarhus University Hospital, Department of Endocrinology
  More Information

Responsible Party: University of Aarhus Identifier: NCT00682084     History of Changes
Other Study ID Numbers: MM-ISC-20070131
Study First Received: May 20, 2008
Last Updated: December 2, 2014

Keywords provided by University of Aarhus:
Cushing's syndrome
Glucose tolerance
Insulin sensitivity
Substrate metabolism
Body composition

Additional relevant MeSH terms:
Insulin Resistance
Cushing Syndrome
Pathologic Processes
Immune System Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Adrenocortical Hyperfunction
Adrenal Gland Diseases
Endocrine System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on May 25, 2017