Ultrasound Guided Embryo Transfer: Abdominal Versus Transvaginal, a RCT

This study has been completed.
Information provided by (Responsible Party):
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
First received: May 16, 2008
Last updated: October 1, 2015
Last verified: May 2008
Ultrasound (US) guided embryo transfer (ET) appears to improve pregnancy outcomes in IVF-ET. Most reports are done using a transabdominal (TAS) approach, in contrast to a transvaginal ultrasound (TVS) which does not require a full bladder. We sought to determine if either approach was better with respect to clinical outcomes.

in Vitro Fertilization

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Abdominal Versus Transvaginal Ultrasound Guided Embryo Transfer: Results of a Randomized Clinical Trial

Resource links provided by NLM:

Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • pregnancy rates for TAS and TVS ultrasound-guided ET groups [ Time Frame: August 2003 to June 2007 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Length of time required for embryo transfer [ Time Frame: August 2003 to June 2007 ] [ Designated as safety issue: No ]
  • differences between transferring physicians [ Time Frame: August 2003 to June 2007 ] [ Designated as safety issue: No ]
  • multiple pregnancies [ Time Frame: August 2003 to June 2007 ] [ Designated as safety issue: No ]
  • ectopic pregnancy rates [ Time Frame: August 2003 to June 2007 ] [ Designated as safety issue: No ]

Enrollment: 224
Study Start Date: August 2003
Study Completion Date: June 2007
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)
transabdominal ultrasound (TAS) guided embryo transfer
transvaginal ultrasound (TVS) guided embryo transfer


Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients undergoing assisted reproductive cycles at the University of Wisconsin REI Program

Inclusion Criteria:

- All patients undergoing assisted reproductive cycles including autologous IVF, oocyte donation, and frozen embryo transfer (FET) cycles

Exclusion Criteria:

- Cases of severe ovarian hyper-stimulation requiring embryo cryopreservation and gestational surrogate cycles

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00682071

Sponsors and Collaborators
University of Wisconsin, Madison
Principal Investigator: Steven R Lindheim, MD, MMM Fertility Specialists Medical Group
  More Information

Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT00682071     History of Changes
Other Study ID Numbers: 2003-311  IRB# 2003-311 (UW)  HSC# 2003-311 (UW)  Grant: OB/GYN R&D  Funding # 133-FZ71 
Study First Received: May 16, 2008
Last Updated: October 1, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by University of Wisconsin, Madison:
embryo transfer
in-vitro fertilization

ClinicalTrials.gov processed this record on May 24, 2016