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Quality of Life After Liver Resection

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ClinicalTrials.gov Identifier: NCT00681499
Recruitment Status : Completed
First Posted : May 21, 2008
Last Update Posted : November 13, 2015
Information provided by:
University of Bern

Brief Summary:
Patients with malignant diseases are increasingly receiving more extensive hepatic resections, with im-proved preoperative and postoperative care leading to a reduced postoperative morbidity and mortality. In this setting, postoperative quality of life may become as important as overall patient survival. In this study we will be investigating the effect of the initial disease for which hepatic resection was carried out on short- and long-term quality of life.

Condition or disease
Liver Diseases Liver Neoplasms

Detailed Description:

Background: Due to advances in operative methods and perioperative care, mortality and morbidity following major hepatic resection have decreased substantially, making long-term quality of life (QoL) an increasingly prominent issue.

Objectives: We plan on evaluating whether postoperative diagnosis is associated with long-term QoL and health in patients who require hepatic surgery for benign or malignant diseases and how QoL evolves with time.

Method: QoL will be evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and the liver-specific QLQ-LMC21 module. All patients requiring hepatic surgery aged >18 years will be included in the study. QoL evaluation is carried out preoperatively and at set intervals postoperatively.

Study Type : Observational
Actual Enrollment : 198 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Long-term Evaluation of the Quality of Life After Major Hepatic Resection for Malignant and Benign Diseases.
Study Start Date : February 2008
Primary Completion Date : January 2014
Study Completion Date : January 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Liver Cancer
U.S. FDA Resources

eg. hepatocellular carcinoma, colorectal liver metastases
eg. liver cysts, traumatic liver injuries, adenoma etc

Primary Outcome Measures :
  1. Quality of Life [ Time Frame: preoperatively, 1-,3-,6-,12 months postoperatively ]

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients requiring liver resection for any benign or malignant liver diseases, including secondary tumours

Inclusion Criteria:

  • Patients with planned liver resection

Exclusion Criteria

  • Patients with biopsy of the liver only
  • Inability of understanding the questionnaire

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00681499

Department of visceral and transplant surgery, Bern University Hospital
Bern, Switzerland, 3010
Sponsors and Collaborators
University of Bern
Principal Investigator: Vanessa Banz, MD Dep. of Visceral and transplant Surgery, University Hospital Berne, Switzerland


Responsible Party: Vanessa Banz, MD, Dep. of Visceral and Transplant surgery, Bern University Hospital, Switzerland
ClinicalTrials.gov Identifier: NCT00681499     History of Changes
Other Study ID Numbers: KEK 18/08
First Posted: May 21, 2008    Key Record Dates
Last Update Posted: November 13, 2015
Last Verified: November 2015

Keywords provided by University of Bern:
Quality of Life
Liver Neoplasms
Surgical procedures, Operative

Additional relevant MeSH terms:
Liver Diseases
Liver Neoplasms
Digestive System Diseases
Digestive System Neoplasms
Neoplasms by Site