Quality of Life After Liver Resection
Patients with malignant diseases are increasingly receiving more extensive hepatic resections, with im-proved preoperative and postoperative care leading to a reduced postoperative morbidity and mortality. In this setting, postoperative quality of life may become as important as overall patient survival. In this study we will be investigating the effect of the initial disease for which hepatic resection was carried out on short- and long-term quality of life.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Long-term Evaluation of the Quality of Life After Major Hepatic Resection for Malignant and Benign Diseases.|
- Quality of Life [ Time Frame: preoperatively, 1-,3-,6-,12 months postoperatively ] [ Designated as safety issue: No ]
|Study Start Date:||February 2008|
|Estimated Study Completion Date:||January 2014|
|Primary Completion Date:||January 2013 (Final data collection date for primary outcome measure)|
eg. hepatocellular carcinoma, colorectal liver metastases
eg. liver cysts, traumatic liver injuries, adenoma etc
Background: Due to advances in operative methods and perioperative care, mortality and morbidity following major hepatic resection have decreased substantially, making long-term quality of life (QoL) an increasingly prominent issue.
Objectives: We plan on evaluating whether postoperative diagnosis is associated with long-term QoL and health in patients who require hepatic surgery for benign or malignant diseases and how QoL evolves with time.
Method: QoL will be evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and the liver-specific QLQ-LMC21 module. All patients requiring hepatic surgery aged >18 years will be included in the study. QoL evaluation is carried out preoperatively and at set intervals postoperatively.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00681499
|Department of visceral and transplant surgery, Bern University Hospital|
|Bern, Switzerland, 3010|
|Principal Investigator:||Vanessa Banz, MD||Dep. of Visceral and transplant Surgery, University Hospital Berne, Switzerland|