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Adolescent Substance Abuse: Progressive Treatment (ADAPT)

This study has been completed.
Information provided by (Responsible Party):
Oregon Research Institute Identifier:
First received: May 16, 2008
Last updated: October 8, 2014
Last verified: October 2014
The purpose of this study is to find out more about how to provide effective further treatment for adolescents who have received six weeks of group therapy for substance-use problems and continue to use drugs. Treatments used in the study include a group therapy (MET/CBT), an individual therapy (CBT), and a family therapy (FFT). The study will look at whether abstinence or a very low level of use is a better guide for deciding whether further treatment is needed, how well different combinations of treatment work to reduce substance use, and whether it is possible to predict in advance which adolescents will respond best to which types of treatment. Study investigators expect that a treatment strategy using what is learned about these issues in the first half of the project to develop an "adaptive" treatment model will work better than a "fixed" treatment to reduce adolescent substance use.

Condition Intervention Phase
Substance Abuse
Behavioral: CBT, Cognitive Behavioral Therapy
Behavioral: FFT, Family Functional Therapy
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment

Further study details as provided by Oregon Research Institute:

Primary Outcome Measures:
  • Urine drug screens [ Time Frame: Pretx, 6, 14 and 22 weeks, 3 and 6 months after initial treatment session ]

Enrollment: 140
Study Start Date: March 2008
Study Completion Date: August 2013
Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Eight weeks of individual CBT for adolescents who have completed six weeks of group therapy and continue to use drugs.
Behavioral: CBT, Cognitive Behavioral Therapy
Eight weekly sessions of individual Cognitive Behavioral Therapy, to develop skills enabling adolescents stop or reduce their drug use.
Active Comparator: 2
Eight weeks of FFT for adolescents who have received six weeks of group therapy and continue to use drugs.
Behavioral: FFT, Family Functional Therapy
Eight weekly sessions of Functional Family Therapy designed to strengthen family relationships and build skills to help the adolescent stop or reduce his/her drug use.


Ages Eligible for Study:   13 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. 13 to 18 years if age
  2. Meet DSM-IV (APA, 1994) diagnostic criteria for substance abuse or dependence
  3. Live in the Albuquerque metropolitan area or surrounding communities
  4. Sufficient residential stability to permit probable contact at follow-up (e.g., not homeless at time of intake).

Exclusion Criteria:

  1. There is evidence of psychotic or organic state of sufficient severity to interfere with the understanding of study instruments and procedures
  2. The adolescent is deemed dangerous to self or others during evaluation
  3. Services other than outpatient treatment are required for the adolescent (e.g., inpatient, detoxification)
  4. Marijuana use is reported as being less than 13% of days in the previous 90 days.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00680576

United States, New Mexico
Oregon Res. Inst. Center for Family & Adolescent Research (CFAR)
Albuquerque, New Mexico, United States, 87102
Sponsors and Collaborators
Oregon Research Institute
Principal Investigator: Holly B Waldron, Ph.D. Oregon Research Institute Center for Family and Adolescent Research (ORI/CFAR)
  More Information

Responsible Party: Oregon Research Institute Identifier: NCT00680576     History of Changes
Other Study ID Numbers: DA023568
R01DA023568 ( US NIH Grant/Contract Award Number )
Study First Received: May 16, 2008
Last Updated: October 8, 2014

Keywords provided by Oregon Research Institute:
adolescent substance abuse

Additional relevant MeSH terms:
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders processed this record on May 25, 2017