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Adolescent Substance Abuse: Progressive Treatment (ADAPT)

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ClinicalTrials.gov Identifier: NCT00680576
Recruitment Status : Completed
First Posted : May 20, 2008
Last Update Posted : October 10, 2014
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to find out more about how to provide effective further treatment for adolescents who have received six weeks of group therapy for substance-use problems and continue to use drugs. Treatments used in the study include a group therapy (MET/CBT), an individual therapy (CBT), and a family therapy (FFT). The study will look at whether abstinence or a very low level of use is a better guide for deciding whether further treatment is needed, how well different combinations of treatment work to reduce substance use, and whether it is possible to predict in advance which adolescents will respond best to which types of treatment. Study investigators expect that a treatment strategy using what is learned about these issues in the first half of the project to develop an "adaptive" treatment model will work better than a "fixed" treatment to reduce adolescent substance use.

Condition or disease Intervention/treatment Phase
Substance Abuse Behavioral: CBT, Cognitive Behavioral Therapy Behavioral: FFT, Family Functional Therapy Phase 1

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 140 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : March 2008
Primary Completion Date : August 2013
Study Completion Date : August 2013
Arms and Interventions

Arm Intervention/treatment
Active Comparator: 1
Eight weeks of individual CBT for adolescents who have completed six weeks of group therapy and continue to use drugs.
Behavioral: CBT, Cognitive Behavioral Therapy
Eight weekly sessions of individual Cognitive Behavioral Therapy, to develop skills enabling adolescents stop or reduce their drug use.
Active Comparator: 2
Eight weeks of FFT for adolescents who have received six weeks of group therapy and continue to use drugs.
Behavioral: FFT, Family Functional Therapy
Eight weekly sessions of Functional Family Therapy designed to strengthen family relationships and build skills to help the adolescent stop or reduce his/her drug use.

Outcome Measures

Primary Outcome Measures :
  1. Urine drug screens [ Time Frame: Pretx, 6, 14 and 22 weeks, 3 and 6 months after initial treatment session ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   13 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. 13 to 18 years if age
  2. Meet DSM-IV (APA, 1994) diagnostic criteria for substance abuse or dependence
  3. Live in the Albuquerque metropolitan area or surrounding communities
  4. Sufficient residential stability to permit probable contact at follow-up (e.g., not homeless at time of intake).

Exclusion Criteria:

  1. There is evidence of psychotic or organic state of sufficient severity to interfere with the understanding of study instruments and procedures
  2. The adolescent is deemed dangerous to self or others during evaluation
  3. Services other than outpatient treatment are required for the adolescent (e.g., inpatient, detoxification)
  4. Marijuana use is reported as being less than 13% of days in the previous 90 days.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00680576

United States, New Mexico
Oregon Res. Inst. Center for Family & Adolescent Research (CFAR)
Albuquerque, New Mexico, United States, 87102
Sponsors and Collaborators
Oregon Research Institute
Principal Investigator: Holly B Waldron, Ph.D. Oregon Research Institute Center for Family and Adolescent Research (ORI/CFAR)
More Information

Responsible Party: Oregon Research Institute
ClinicalTrials.gov Identifier: NCT00680576     History of Changes
Other Study ID Numbers: DA023568
R01DA023568 ( U.S. NIH Grant/Contract )
First Posted: May 20, 2008    Key Record Dates
Last Update Posted: October 10, 2014
Last Verified: October 2014

Keywords provided by Oregon Research Institute:
adolescent substance abuse

Additional relevant MeSH terms:
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders