A Study of INS365 Ophthalmic Solution in Patients With Moderate to Severe Dry Eye Disease
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A Multi-Center, Double-Masked, Randomized, Placebo-Controlled, Dose-Ranging Study of Multiple Ocular Instillations of INS365 Ophthalmic Solution vs. Placebo in Patients With Moderate to Severe Dry Eye Disease
Study Start Date
Primary Completion Date
Study Completion Date
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Ages Eligible for Study:
Child, Adult, Senior
Best corrected visual acuity of at least +0.7 ETDRS
Six month history of dry eye disease
Mild severity in two out of five symptoms
Unanesthetized Schirmer score of less than or equal to 7mm
Corneal fluorescein staining greater than or equal to 4 out of 15 or lissamine green conjunctival staining of greater than or equal to 5 out of 18
Nasal stimulated Schirmer score of less than 3mm
Have ongoing ocular infection
Have congenitally absent meibomian or lacrimal glands
Have had punctal occlusion within a specified time prior to study