Evaluation the Growth Factors(IGF-1,IGFBP-3and HGH)in Patients With Chronic Liver Disease
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|ClinicalTrials.gov Identifier: NCT00679692|
Recruitment Status : Completed
First Posted : May 19, 2008
Last Update Posted : May 19, 2008
BACKGROUND The insulin-like growth factor system (IGFs) plays an important role in cell growth and differentiation. Nevertheless, the roles played by insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and human growth hormone (HGH) in the progression of chronic liver disease remain to be elucidated and investigated.
METHODS The subjects in the present study included 60 healthy controls, 30 hepatitis patients, 60 liver cirrhosis patients and 60 untreated hepatocellular carcinoma patients. Blood was drawn by venipuncture into Venoject tubes. To find the possible correlations between liver damage and IGFs, serum IGF-1, GH, IGFBP-3 concentration and related biochemical parameters were measured. We used immunoradiometric assay to determine the levels of IGF-1, HGH and IGFBP-3 in serum.
|Condition or disease|
|Hepatitis Liver Cirrhosis Hepatocellular Carcinoma|
|Study Type :||Observational|
|Actual Enrollment :||210 participants|
|Official Title:||Insulin-Like Growth Factor-1,Insulin-Like Growth Factor Binding Protein-3 and Human Growth Hormone in Serum of Patients With Chronic Liver Disease and Possible Clinical Applications.|
|Study Start Date :||September 2006|
|Actual Primary Completion Date :||March 2008|
|Actual Study Completion Date :||March 2008|
three arms for study
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00679692
|Division of Radio immunoassay lab,Department of Nuclear Medical University Hospital,No.100 Tzyou 1st Road|
|Principal Investigator:||chiou m Lin, Ms||Kaohsiung Medical University|