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Association Between Deficiency of MBL (Mannose-Binding Lectin) and Polymorphisms in MBL2 Gene to Urinary Tract Infection

This study has been completed.
Information provided by:
HaEmek Medical Center, Israel Identifier:
First received: February 17, 2008
Last updated: April 22, 2009
Last verified: April 2009
Due to genetic polymorphism about 15%-30% of the world population have low levels of MBL (Mannose Binding Lectin) in serum (below 500ng/mL). Different studies reported correlation between polymorphism in the MBL gene with low levels of MBL in serum and higher frequency of recurrent infections, severity of sepsis, ARDS and other infections. Urinary Tract Infection (UTI) is one of the very common infection in women. Since MBL is part of the innate immunity and there are proofs of relation between patients with recurrent infections and lack of MBL, we decided to explore a possible relation between low levels of MBL and different genotypes of MBL in young women and the risk to develop recurrent UTI.

Recurrent Urinary Tract Infections

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Association Between Deficiency of MBL (Mannose-Binding Lectin) and Polymorphisms in MBL2 Gene to Urinary Tract Infection

Resource links provided by NLM:

Further study details as provided by HaEmek Medical Center, Israel:

Biospecimen Retention:   Samples With DNA
whole blood for genetic test and serum for MBL test

Estimated Enrollment: 200
Study Start Date: February 2008

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
young women with recurrent UTI - study group and young women witout recurrent UTI - a control group

Inclusion Criteria:

  • women above 18 years old.
  • premenopausal
  • recurrent UTI

Exclusion Criteria:

  • pregnancy
  • immunocompromised
  • active malignancy
  • HIV carrier
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Please refer to this study by its identifier: NCT00678028

Ha'Emek Medical Center
Afula, Israel, 18101
Sponsors and Collaborators
HaEmek Medical Center, Israel
  More Information

Responsible Party: Dr. Orna Nitzan, Ha'emek Medical Center, Afula, Israel Identifier: NCT00678028     History of Changes
Other Study ID Numbers: 0080-07-EMC
Study First Received: February 17, 2008
Last Updated: April 22, 2009

Keywords provided by HaEmek Medical Center, Israel:

Additional relevant MeSH terms:
Communicable Diseases
Urinary Tract Infections
Urologic Diseases processed this record on May 25, 2017