Impact of Microparticles on Postoperative Complications in Surgical Patients

This study has been completed.
Information provided by:
University of Bern Identifier:
First received: May 8, 2008
Last updated: September 5, 2011
Last verified: September 2011
Microparticles are cellular fragments which are released actively or passively under conditions of inflammation and stress. The impact of surgical operations on quantity and quality of microparticles remains unknown. In this observatory study we investigate quantitative and qualitative aspects of microparticles during cardiac and abdominal operations.

Neoplasm, Hepatic
Pancreatic Neoplasms
Colorectal Neoplasms

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Impact of Microparticles on Inflammatory Responses During Visceral and Cardiac Surgery

Resource links provided by NLM:

Further study details as provided by University of Bern:

Primary Outcome Measures:
  • Postoperative morbidity [ Time Frame: 30 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Hospital stay [ Time Frame: 30 days ] [ Designated as safety issue: No ]
  • Mortality [ Time Frame: 30 days ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Enrollment: 108
Study Start Date: February 2008
Study Completion Date: January 2010
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
We investigate a cohort of 20 consecutive patients undergoing hepatic or pancreatic surgery (Pilot study)


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing cardiac or hepatobiliary or colorectal surgery. Setting: university hospital.

Inclusion Criteria:

  • Patients undergoing cardiac or abdominal operations with a minimum expected operative time of 2 hours

Exclusion Criteria:

  • Laparoscopic operations
  • emergency operations
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Please refer to this study by its identifier: NCT00677781

Department of visceral and transplant surgery, Bern University Hospital
Bern, Switzerland, 3010
Sponsors and Collaborators
University of Bern
Principal Investigator: Guido Beldi, MD Bern University Hospital
  More Information


Responsible Party: Guido Beldi, MD, Department of visceral and transplant surgery, Inselspital Bern, Switzerland Identifier: NCT00677781     History of Changes
Other Study ID Numbers: KEK251_07 
Study First Received: May 8, 2008
Last Updated: September 5, 2011
Health Authority: Switzerland: Ethikkommission

Additional relevant MeSH terms:
Colorectal Neoplasms
Liver Neoplasms
Pancreatic Neoplasms
Postoperative Complications
Colonic Diseases
Digestive System Diseases
Digestive System Neoplasms
Endocrine Gland Neoplasms
Endocrine System Diseases
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Intestinal Diseases
Intestinal Neoplasms
Liver Diseases
Neoplasms by Site
Pancreatic Diseases
Pathologic Processes
Rectal Diseases processed this record on February 10, 2016