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Impact of Microparticles on Postoperative Complications in Surgical Patients

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ClinicalTrials.gov Identifier: NCT00677781
Recruitment Status : Completed
First Posted : May 15, 2008
Last Update Posted : September 7, 2011
Information provided by:
University of Bern

Brief Summary:
Microparticles are cellular fragments which are released actively or passively under conditions of inflammation and stress. The impact of surgical operations on quantity and quality of microparticles remains unknown. In this observatory study we investigate quantitative and qualitative aspects of microparticles during cardiac and abdominal operations.

Condition or disease
Neoplasm, Hepatic Pancreatic Neoplasms Colorectal Neoplasms

Study Type : Observational
Actual Enrollment : 108 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Impact of Microparticles on Inflammatory Responses During Visceral and Cardiac Surgery
Study Start Date : February 2008
Primary Completion Date : December 2008
Study Completion Date : January 2010

We investigate a cohort of 20 consecutive patients undergoing hepatic or pancreatic surgery (Pilot study)

Primary Outcome Measures :
  1. Postoperative morbidity [ Time Frame: 30 days ]

Secondary Outcome Measures :
  1. Hospital stay [ Time Frame: 30 days ]
  2. Mortality [ Time Frame: 30 days ]

Biospecimen Retention:   Samples Without DNA

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing cardiac or hepatobiliary or colorectal surgery. Setting: university hospital.

Inclusion Criteria:

  • Patients undergoing cardiac or abdominal operations with a minimum expected operative time of 2 hours

Exclusion Criteria:

  • Laparoscopic operations
  • emergency operations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00677781

Department of visceral and transplant surgery, Bern University Hospital
Bern, Switzerland, 3010
Sponsors and Collaborators
University of Bern
Principal Investigator: Guido Beldi, MD Bern University Hospital


Responsible Party: Guido Beldi, MD, Department of visceral and transplant surgery, Inselspital Bern, Switzerland
ClinicalTrials.gov Identifier: NCT00677781     History of Changes
Other Study ID Numbers: KEK251_07
First Posted: May 15, 2008    Key Record Dates
Last Update Posted: September 7, 2011
Last Verified: September 2011

Additional relevant MeSH terms:
Postoperative Complications
Colorectal Neoplasms
Pancreatic Neoplasms
Liver Neoplasms
Pathologic Processes
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
Endocrine Gland Neoplasms
Pancreatic Diseases
Endocrine System Diseases
Liver Diseases