Adrenal Exhaustion Syndrome in Critically Ill Patients Without Improvement
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|ClinicalTrials.gov Identifier: NCT00674284|
Recruitment Status : Completed
First Posted : May 7, 2008
Last Update Posted : November 25, 2009
|Condition or disease|
Elevated corticosteroid level to meet physiologic needs during acute illness is a protective response for stress. This homeostasis is maintained by the hypothalamic-pituitary-adrenal (HPA) axis. However, inadequate response as corticosteroid insufficiency in critically ill patients is reported with increasing frequency, especially in severe sepsis and septic shock. Thus, corticosteroids could be beneficial for septic shock or severe acute illness.
Once considered as normal adrenal function, adrenal insufficiency may developed later with chronic critical illness as adrenal exhaustion syndrome. It is easily overlooked and is possible due to the chronic secretion of systemic cytokines or other HPA axis-suppressive substances. There is still no consensus how often adrenal function testing should be repeated, although a re-evaluation should be considered if clinical symptoms and signs suggest adrenal insufficiency or deteriorating clinical condition.
|Study Type :||Observational|
|Actual Enrollment :||80 participants|
|Official Title:||Change of Serum Cortisol Levels in Patients Without Improvement in Intensive Care Unit|
|Study Start Date :||February 2008|
|Actual Primary Completion Date :||May 2008|
|Actual Study Completion Date :||May 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00674284
|Taipei, Taiwan, 100|
|Study Director:||Chao-Chi Ho, MD||1. Department of Internal Medicine, National Taiwan University Hospital|