Adrenal Exhaustion Syndrome in Critically Ill Patients Without Improvement

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00674284
Recruitment Status : Completed
First Posted : May 7, 2008
Last Update Posted : November 25, 2009
Information provided by:
National Taiwan University Hospital

Brief Summary:
We study the relationship between patient outcomes and sequential changes of serum cortisol level.

Condition or disease

Detailed Description:

Elevated corticosteroid level to meet physiologic needs during acute illness is a protective response for stress. This homeostasis is maintained by the hypothalamic-pituitary-adrenal (HPA) axis. However, inadequate response as corticosteroid insufficiency in critically ill patients is reported with increasing frequency, especially in severe sepsis and septic shock. Thus, corticosteroids could be beneficial for septic shock or severe acute illness.

Once considered as normal adrenal function, adrenal insufficiency may developed later with chronic critical illness as adrenal exhaustion syndrome. It is easily overlooked and is possible due to the chronic secretion of systemic cytokines or other HPA axis-suppressive substances. There is still no consensus how often adrenal function testing should be repeated, although a re-evaluation should be considered if clinical symptoms and signs suggest adrenal insufficiency or deteriorating clinical condition.

Study Type : Observational
Actual Enrollment : 80 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Change of Serum Cortisol Levels in Patients Without Improvement in Intensive Care Unit
Study Start Date : February 2008
Actual Primary Completion Date : May 2008
Actual Study Completion Date : May 2008

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All of the adult patients (age >18 years) admitted to the intensive care units of the National Taiwan University Hospital between January 2005 and December 2006 were surveyed.

Inclusion Criteria:

  • age over 18
  • ICU admission
  • had two cortisol data

Exclusion Criteria:

  • first cortisol data abnormal
  • cortisol data not checked in ICU

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00674284

Chao-Chi Ho
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Chao-Chi Ho, MD 1. Department of Internal Medicine, National Taiwan University Hospital

Responsible Party: Chao-Chi Ho, National Taiwan University Hospital Identifier: NCT00674284     History of Changes
Other Study ID Numbers: 200802022R
First Posted: May 7, 2008    Key Record Dates
Last Update Posted: November 25, 2009
Last Verified: November 2009