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Effects of Glutamine on GLP-1 and Insulin Secretion in Man

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2008 by Garvan Institute of Medical Research.
Recruitment status was:  Recruiting
Information provided by:
Garvan Institute of Medical Research Identifier:
First received: May 6, 2008
Last updated: June 19, 2008
Last verified: June 2008
This study will investigate the effect of glutamine, an amino acid, on GLP-1, insulin and glycaemia in normal lean subjects and patients with type 2 diabetes.

Condition Intervention Phase
Type 2 Diabetes
Drug: Glutamine, sitagliptin
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Study of the Effects of Glutamine on GLP-1, Insulin Secretion and Glycaemia in Man

Resource links provided by NLM:

Further study details as provided by Garvan Institute of Medical Research:

Primary Outcome Measures:
  • Post-prandial glucose [ Time Frame: 180 min ]

Secondary Outcome Measures:
  • GLP-1 [ Time Frame: 180 min ]

Estimated Enrollment: 20
Study Start Date: April 2008
Estimated Study Completion Date: June 2010
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Glutamine, sitagliptin
    Glutamine 15g and 30g/sitagliptin 100mg
    Other Name: Januvia
Detailed Description:
In this study, will investigate the effect of glutamine, an amino acid, on GLP-1, insulin and glycaemia in normal lean subjects and patients with type 2 diabetes. Preliminary data published by our group suggests that glutamine is a strong determinant of GLP-1 secretion in vitro. We will test the hypothesis that glutamine lowers post-prandial glucose levels. We will also investigate whether sitagliptin modifies this effect.

Ages Eligible for Study:   25 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy subjects (lean) or type 2 diabetes, on metformin or diet alone (not sulphonylureas or insulin)

Exclusion Criteria:

  • malabsorption, renal or liver disease, using steroids
  Contacts and Locations
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Please refer to this study by its identifier: NCT00673894

Contact: Jerry R Greenfield 612-9295-8217

Australia, New South Wales
Clinical Research Facility Recruiting
Sydney, New South Wales, Australia, 2010
Contact: Dr J Greenfield, FRACP    612-9295-8100 ext 8217   
Principal Investigator: Jerry Greenfield, FRACP         
Sponsors and Collaborators
Garvan Institute of Medical Research
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Jerry Greenfield, Garvan Institute of Medical Research Identifier: NCT00673894     History of Changes
Other Study ID Numbers: H07/059
Study First Received: May 6, 2008
Last Updated: June 19, 2008

Additional relevant MeSH terms:
Sitagliptin Phosphate
Hypoglycemic Agents
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Dipeptidyl-Peptidase IV Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on May 23, 2017