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Neurotoxic Health Hazards of Long-Term Low-Level Exposure to Organophosphate (OP) Compounds in in Hula Valley

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2008 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Shaare Zedek Medical Center Identifier:
First received: April 30, 2008
Last updated: May 4, 2008
Last verified: April 2008
During 1987-1991, WHO supported studies of exposures and short term neurobehavioral effects in a cohort (n=200) with occupational and community exposures to pesticide drift containing organophosphates from orchards and cotton fields in the Hula Valley. We aim (1) to re-examine neurobehavioral outcomes in members of the original cohort and (2) to examine cognitive effects in children with residential exposures. In adults, we will carry out assays of alkyl phosphates, PON1 (paraoxonase-1), NTE (Neuropathy Target Esterase), neurobehavioral tests of cognitive and performance skills, nerve conduction measurements and mood status. We will carry out Psycho-Didactic tests in children. The findings will advance knowledge on delayed term health effects of lengthy everyday exposure to OP pesticides and guide regulatory policy.

Peripheral Neuropathy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional

Further study details as provided by Shaare Zedek Medical Center:

Agricultural Workers
Non - Agricultural Workers
Kibbitz Residents working else where


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Residents of Kibbutzim

Inclusion Criteria:

  • Participants of the former study twenty years ago
  Contacts and Locations
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Please refer to this study by its identifier: NCT00671866

Neurology and Toxicology Unit and Service, Shaare Zedek Med Ctr Not yet recruiting
Jerusalem, Israel, 91031
Contact: Yoram Finkelstein, MD PhD    972-2-6555655   
Principal Investigator: Yoram Finkelstein, MD PhD         
Sponsors and Collaborators
Shaare Zedek Medical Center
  More Information Identifier: NCT00671866     History of Changes
Other Study ID Numbers: y.finkelstein.ctil.
Study First Received: April 30, 2008
Last Updated: May 4, 2008

Keywords provided by Shaare Zedek Medical Center:
Long-Term Low Level Exposure
Occupational Health
Neurobehavioral Effects

Additional relevant MeSH terms:
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases processed this record on September 20, 2017