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Neurotoxic Health Hazards of Long-Term Low-Level Exposure to Organophosphate (OP) Compounds in in Hula Valley

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ClinicalTrials.gov Identifier: NCT00671866
Recruitment Status : Unknown
Verified April 2008 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : May 5, 2008
Last Update Posted : May 5, 2008
Information provided by:
Shaare Zedek Medical Center

Brief Summary:
During 1987-1991, WHO supported studies of exposures and short term neurobehavioral effects in a cohort (n=200) with occupational and community exposures to pesticide drift containing organophosphates from orchards and cotton fields in the Hula Valley. We aim (1) to re-examine neurobehavioral outcomes in members of the original cohort and (2) to examine cognitive effects in children with residential exposures. In adults, we will carry out assays of alkyl phosphates, PON1 (paraoxonase-1), NTE (Neuropathy Target Esterase), neurobehavioral tests of cognitive and performance skills, nerve conduction measurements and mood status. We will carry out Psycho-Didactic tests in children. The findings will advance knowledge on delayed term health effects of lengthy everyday exposure to OP pesticides and guide regulatory policy.

Condition or disease
Peripheral Neuropathy

Study Type : Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional

Agricultural Workers
Non - Agricultural Workers
Kibbitz Residents working else where

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Residents of Kibbutzim

Inclusion Criteria:

  • Participants of the former study twenty years ago

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00671866

Neurology and Toxicology Unit and Service, Shaare Zedek Med Ctr Not yet recruiting
Jerusalem, Israel, 91031
Contact: Yoram Finkelstein, MD PhD    972-2-6555655    yoramf@ekmd.huji.ac.il   
Principal Investigator: Yoram Finkelstein, MD PhD         
Sponsors and Collaborators
Shaare Zedek Medical Center

ClinicalTrials.gov Identifier: NCT00671866     History of Changes
Other Study ID Numbers: y.finkelstein.ctil.
First Posted: May 5, 2008    Key Record Dates
Last Update Posted: May 5, 2008
Last Verified: April 2008

Keywords provided by Shaare Zedek Medical Center:
Long-Term Low Level Exposure
Occupational Health
Neurobehavioral Effects

Additional relevant MeSH terms:
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases