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Cost-Effectiveness Analysis of Rotavirus Vaccination for Children in Korea

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2009 by Yonsei University.
Recruitment status was:  Recruiting
Merck Sharp & Dohme Corp.
Severance Hospital
Information provided by:
Yonsei University Identifier:
First received: April 29, 2008
Last updated: February 18, 2009
Last verified: February 2009
The primary objective of the proposed project is to estimate the economic impact of a national rotavirus immunization program in preventing rotavirus diarrhea among Korean children.

Rotavirus Vaccines

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Cost-Effectiveness Analysis of Rotavirus Vaccination for Children in Korea

Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • patients' cost [ Time Frame: one year ]

Estimated Enrollment: 200
Study Start Date: May 2008
Estimated Study Completion Date: June 2009
Estimated Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
patients visited to Severance hospital
patients visited to Youngdong Severance hospital
patients visited to Wonju Christian hospital

Detailed Description:
Rotavirus is the leading cause of severe acute diarrhea or gastroenteritis among young children worldwide. In the first 5 years of life, about 90% of children experience at least one episode of rotavirus infection.Each year, rotavirus diarrhea is responsible for 440,000 deaths, 2 million hospitalizations, and 25 million outpatient visits among children younger than 5 years worldwide. In South Korea, rotavirus diarrhea rarely causes mortality, but it cause significant morbidity. A recent population-based study in Korea has estimated that the annual incidence of rotavirus diarrhea accounts for 56.9 cases per 1,000 children less than 5 years old. Oral, live pentavalent human-bovine reassortant rotavirus vaccine has been developed and licensed for the use of preventing rotavirus disease in many countries. Yet, there has been no research done to assess the impact of national rotavirus immunization program in Korea. It is expected that systematic appraisal on the national burden of rotavirus infection and potential public health and economic benefits of rotavirus vaccination for children in Korea will assists health policy makers to set a priority for the prevention of this disease.

Ages Eligible for Study:   up to 5 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients to visit assigned hospital

Inclusion Criteria:

  • children aged under 5 years and diagnosed as acute gastroenteritis

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00669929

Korea, Republic of
Wonju Christian Hospital
Wonju, Kangwon-do, Korea, Republic of
Yonsei University Health System Severance Hospital
Seoul, Korea, Republic of, 120-752
Youngdong Severance Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Yonsei University
Merck Sharp & Dohme Corp.
Severance Hospital
Principal Investigator: Dong Soo Kim, MD, PhD professor
  More Information

Responsible Party: Yonsei University Health System Severance Hospital, Yonsei University Identifier: NCT00669929     History of Changes
Other Study ID Numbers: rota-001  yonsei-rota 
Study First Received: April 29, 2008
Last Updated: February 18, 2009

Keywords provided by Yonsei University:
Cost effectiveness analysis of rotavirus vaccination

Additional relevant MeSH terms:
Gastrointestinal Diseases
Digestive System Diseases
Immunologic Factors
Physiological Effects of Drugs processed this record on February 17, 2017