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An Observational Study of TNKase in Patients Enrolled in the National Registry of Myocardial Infarction 4 and 5 (POST)

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ClinicalTrials.gov Identifier: NCT00669045
Recruitment Status : Completed
First Posted : April 29, 2008
Last Update Posted : February 15, 2017
Sponsor:
Information provided by:
Genentech, Inc.

Brief Summary:
The POST study comprised patients whose data were entered into the NRMI 4 and 5 databases. NRMI is a prospective, observational study of patients presenting with AMI in the United States. NRMI was launched in 1990 and to date has enrolled more than 2.5 million AMI patients. More than 1,700 hospitals have participated in NRMI during the last 16 years. The NRMI 4 and 5 substudies were sponsored by Genentech and collected data on approximately 160,000 AMI patients (both ST elevation and non-ST-elevation MI) hospitalized in the United States each year. This corresponds to approximately 18% of the AMI patients in the United States.

Condition or disease
Acute Myocardial Infarction

Study Type : Observational
Actual Enrollment : 253668 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Phase IV, Prospective, Observational Study of TNKase in Patients Enrolled in the National Registry of Myocardial Infarction 4 and 5 (POST)
Actual Study Start Date : September 1, 2000
Actual Primary Completion Date : March 31, 2006
Actual Study Completion Date : March 31, 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack
U.S. FDA Resources





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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Presence of LBBB or ST-segment elevation (new or of unknown duration)
  • ICD-9-CM discharge code of 410.X1
  • Treatment with one of the following regimens: TNKase; Other thrombolytic regimens; No initial reperfusion

Exclusion Criteria:

  • Patients who were transferred out of the facility
  • Patients with pending data clarification forms on fields related to study variables

ClinicalTrials.gov Identifier: NCT00669045     History of Changes
Other Study ID Numbers: N2224n
First Posted: April 29, 2008    Key Record Dates
Last Update Posted: February 15, 2017
Last Verified: February 2017

Keywords provided by Genentech, Inc.:
TNKase
AMI

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Tenecteplase
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action